Efflux Pumps and Multidrug-Resistance in Pyricularia oryzae Triticum Lineage

SNC Vicentini, SI Moreira, AG da Silva, TYK de Oliveira… - Agronomy, 2022 - mdpi.com
Widespread resistance to QoIs, DMI and SDHIs fungicides has been reported for Brazilian
populations of the wheat blast pathogen Pyricularia oryzae Triticum lineage (PoT l). A pre …

The RNA helicase Ski2 in the fungal pathogen Cryptococcus neoformans highlights key roles in azoles resistance and stress tolerance

C Li, X Ma, L Ma, S Zhen, Y Na, P Zhang… - Medical …, 2022 - academic.oup.com
The yeast SKI (superkiller) complex was originally identified from cells that were infected by
the M 'killer'virus. Ski2, as the core of the SKI complex, is a cytoplasmic cofactor and …

CRYPTOCOCCOSIS: A bibliographic narrative review on antifungal resistance

MIT Kakizaki, MDESC Melhem - Anais da Academia Brasileira de …, 2023 - SciELO Brasil
Cryptococcosis is an infectious fungal disease widely studied for its epidemiological
importance in the context of public health, given the high morbidity and mortality associated …

Investigation of fluconazole heteroresistance in clinical and environmental isolates of Cryptococcus neoformans complex and Cryptococcus gattii complex in the …

IMB Moreira, ACA Cortez, ÉS de Souza… - Medical …, 2022 - academic.oup.com
Heteroresistance, defined as the occurrence of apparently homogeneous subpopulations of
microbial cells showing different levels of antimicrobial susceptibility is a problem that has …

Fluconazole Resistance and Virulence in In Vitro Induced-Fluconazole Resistant Strains and in Clinical Fluconazole Resistant Strain of Cryptococcus deuterogattii

S Bertout, L Laroche, F Roger, D Krasteva… - Pathogens, 2023 - mdpi.com
Neuromeningeal cryptococcosis is a life-threatening infection of the central nervous system,
caused by encapsulated yeast belonging to the Cryptococcus neoformans and …

Hypervirulence and cross-resistance to a clinical antifungal are induced by an environmental fungicide in Cryptococcus gattii

HCS Carneiro, RW Bastos, NQ Ribeiro… - Science of the Total …, 2020 - Elsevier
The increasing human population requires ongoing efforts in food production. This is
frequently associated with an increased use of agrochemicals, leading to environmental …

Non-Antibiotic Antimony-Based Antimicrobials

N Gerasimchuk, K Pinks, T Salpadoru, K Cotton… - Molecules, 2022 - mdpi.com
A series of the eight novel organoantimony (V) cyanoximates of Sb (C6H5) 4L composition
was synthesized using the high-yield heterogeneous metathesis reaction between solid AgL …

Pleiotropic roles of LAMMER kinase, Lkh1 in stress responses and virulence of Cryptococcus neoformans

S Kwon, Y Choi, ES Kim, KT Lee, YS Bahn… - Frontiers in Cellular …, 2024 - frontiersin.org
Dual-specificity LAMMER kinases are highly evolutionarily conserved in eukaryotes and
play pivotal roles in diverse physiological processes, such as growth, differentiation, and …

Exploring Cryptococcus neoformans CYP51 and Its Cognate Reductase as a Drug Target

YN Ruma, MV Keniya, BC Monk - Journal of Fungi, 2022 - mdpi.com
Cryptococcus remains a leading cause of invasive fungal infections in immunocompromised
people. Resistance to azole drugs has imposed a further challenge to the effective treatment …

Novel ABC Transporter Associated with Fluconazole Resistance in Aging of Cryptococcus neoformans

NK Oliveira, S Bhattacharya, R Gambhir, M Joshi… - Journal of Fungi, 2022 - mdpi.com
Cryptococcus neoformans causes meningoencephalitis in immunocompromised individuals,
which is treated with fluconazole (FLC) monotherapy when resources are limited. This can …