Sepsis is a major cause of death in intensive care units worldwide. The acute phase of
sepsis is often accompanied by sepsis-associated encephalopathy, which is highly …

Sepsis is a systemic inflammatory disease resulting from an infection. This disorder affects
750 000 people annually in the United States and has a 62% rehospitalization rate. Septic …

Assessment and maintenance of end-organ perfusion are key to resuscitation in critical
illness, although there are limited direct methods or proxy measures to assess cerebral …

Cerebral autoregulation (CA) is a physiological mechanism that maintains constant cerebral
blood flow regardless of changes in cerebral perfusion pressure and prevents brain damage …

Background Impaired cerebrovascular reactivity (CVR) is one feature of post cardiac arrest
encephalopathy. We studied the incidence and features of CVR by near infrared …

Objective The pathogenesis of sepsis associated encephalopathy (SAE) remains poorly
understood. Vagus nerve plays an important role in gut-microbiota-brain axis. This study …

Delirium is common during critical illness and is associated with morbidity and mortality, but
its pathophysiology is unknown. We tested whether dysfunctional cerebral autoregulation …

Sepsis-associated encephalopathy (SAE) is one of the most common types of organ
dysfunction without overt central nervous system (CNS) infection. It is associated with higher …

Around the turn of the century, a better understanding of the complex physiology of cerebral
blood flow (CBF) regulation has emerged. It is now acknowledged that cerebral …

Background: Impaired cerebral autoregulation and cerebral hypoperfusion may play a
critical role in the high morbidity and mortality in patients with sepsis-associated …