Potassium channels participate in many biological functions, from ion homeostasis to
generation and modulation of the electrical membrane potential. They are involved in a …

TREK-1 is the most studied background K2P channel. Its main role is to control cell
excitability and maintain the membrane potential below the threshold of depolarization …

The blood-brain barrier (BBB) is an integral part of the neurovascular unit (NVU). The NVU is
comprised of endothelial cells that are interconnected by tight junctions resting on a …

Astrocyte responds to neuronal activity with calcium waves and modulates synaptic
transmission through the release of gliotransmitters. However, little is known about the direct …

Leak currents, defined as voltage and time independent flows of ions across cell
membranes, are central to cellular electrical excitability control. The K 2P (KCNK) potassium …

Depression is a disease that is particularly frequent, affecting up to 20% of the population in
W estern countries. The origins of this pathology involve multiple genes as well as …

Two-pore domain (K 2P) potassium channels are the major molecular correlates of the
background (leak) K+ current in a wide variety of cell types. They generally play a key role in …

Background Intracerebral hemorrhage (ICH) is a devastating medical emergency with high
mortality and severe neurological deficit. ICH-related poor outcomes are due to a …

Two‐pore‐domain potassium (K2P) channels are widespread in the nervous system and
play a critical role in maintaining membrane potential in neurons and glia. They have been …

PKC and PKA phosphorylation inhibit TREK‐1 channels downstream of Gs protein‐coupled
receptor activation in vitro. However, the role of phosphorylation of TREK‐1 in neuropathic …