TREK-1 channel activity is a critical regulator of neuronal, cardiac, and smooth muscle
physiology and pathology. The antidepressant peptide, spadin, has been proposed to be a …

Background The metastasis of tumors into bone tissue typically leads to intractable pain that
is both very disabling and particularly difficult to manage. We investigated here whether …

Two-pore domain K+ (K2P) channels are thought to underlie background K+ conductance in
many cell types. The Trek subfamily of K2P channels consists of three members …

Background and Purpose Opioids are effective painkillers. However, their risk–benefit ratio
is dampened by numerous adverse effects and opioid misuse has led to a public health …

Abstract K2P (KCNK) potassium channels form “background” or “leak” currents that have
critical roles in cell excitability control in the brain, cardiovascular system, and …

Inhibition of the potassium channels TREK‐1 by spadin (SPA) is currently thought to be a
promising therapeutic target for the treatment of depression. Since these channels are …

Depression is a prevalent disease in modern society, and has been linked to stressful
events at early ages. Women are more susceptible to depression, and the neural basis for …

TWIK-related potassium channels (TREK) belong to a subfamily of the two-pore domain
potassium channels family with three members, TREK1, TREK2 and TWIK-related …

Two-pore domain potassium channels (K2P) constitute major candidates for the regulation
of background potassium currents in mammalian cells. Channels of the TREK subfamily are …

Numerous neurological disorders share a fatal pathologic process known as glutamate
excitotoxicity. Among which, ischemic stroke is the major cause of mortality and disability …