Profound effects of dexamethasone on the immunological state, synthesis and secretion capacity of human testicular peritubular cells

YK Stepanov, JD Speidel, C Herrmann, N Schmid… - Cells, 2022 - mdpi.com
The functions of human testicular peritubular cells (HTPCs), forming a small compartment
located between the seminiferous epithelium and the interstitial areas of the testis, are not …

Steroid hormone signaling: multifaceted support of testicular function

S Matsuyama, T DeFalco - Frontiers in Cell and Developmental …, 2024 - frontiersin.org
Embryonic development and adult physiology are dependent on the action of steroid
hormones. In particular, the reproductive system is reliant on hormonal signaling to promote …

Differential susceptibility of male and female germ cells to glucocorticoid-mediated signaling

SA Cincotta, N Richardson, MH Foecke, DJ Laird - Elife, 2024 - elifesciences.org
While physiologic stress has long been known to impair mammalian reproductive capacity
through hormonal dysregulation, mounting evidence now suggests that stress experienced …

Computational systems biology as an animal-free approach to characterize toxicological effects of persistent organic pollutants

Q Wu, R Achebouche, K Audouze - ALTEX-Alternatives to animal …, 2020 - altex.org
Exposure to persistent organic pollutants (POPs), as defined by the Stockholm Convention,
may alter biological systems and cause toxic effects. Computational studies appear to be a …

A novel model using AAV9-cre to knockout adult Leydig cell gene expression reveals a physiological role of glucocorticoid receptor signalling in Leydig cell function

AL Gannon, AL Darbey, G Chensee… - International Journal of …, 2022 - mdpi.com
Glucocorticoids are steroids involved in key physiological processes such as development,
metabolism, inflammatory and stress responses and are mostly used exogenously as …

Promoter polymorphisms in STK35 and IFT27 genes and their associations with boar sperm freezability

A Mańkowska, P Brym, P Sobiech, L Fraser - Theriogenology, 2022 - Elsevier
We have shown that STK35 and IFT27 genes are differentially expressed in spermatozoa
from boars with good and poor semen freezability (GSF and PSF, respectively). STK35 is a …

A network pharmacology approach to determine the underlying mechanisms of action of Yishen Tongluo formula for the treatment of oligoasthenozoospermia

Y Chen, F Bi, Z Sun - Plos one, 2021 - journals.plos.org
Oligoasthenozoospermia is a complex disease caused by a variety of factors, and its
incidence is increasing yearly worldwide. Yishen Tongluo formula (YSTLF), created by …

Gene promoter polymorphisms in boar spermatozoa differing in freezability

P Brym, K Wasilewska-Sakowska… - Theriogenology, 2021 - Elsevier
Single nucleotide polymorphisms (SNPs) in the 5′-flanking regulatory regions of genes
could affect their expression levels. This is a follow-up study aimed to identify polymorphic …

Neonatal corticosterone administration increases p27-positive Sertoli cell number and decreases Sertoli cell number in the testes of mice at prepuberty

H Miyaso, K Takano, K Nagahori, ZL Li, S Kawata… - Scientific Reports, 2022 - nature.com
Cortisol and corticosterone (CORT) are steroid, antistress hormones and one of the
glucocorticoids in humans and animals, respectively. This study evaluated the effects of …

Prolonged exposure to dexamethasone alters the proteome and cellular phenotype of human testicular peritubular cells

YK Stepanov, C Herrmann, JB Stöckl, FM Köhn… - …, 2024 - Wiley Online Library
Human testicular peritubular cells (HTPCs) are smooth muscle cells, which in the testis form
a small compartment surrounding the seminiferous tubules. Contractions of HTPCs are …