Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome

R Lv, X Liu, Y Zhang, N Dong, X Wang, Y He… - Signal transduction and …, 2023 - nature.com
Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …

Diagnosis and management of obstructive sleep apnea: a review

DJ Gottlieb, NM Punjabi - Jama, 2020 - jamanetwork.com
Importance Obstructive sleep apnea (OSA) affects 17% of women and 34% of men in the US
and has a similar prevalence in other countries. This review provides an update on the …

Obstructive sleep apnea in adults

SC Veasey, IM Rosen - New England Journal of Medicine, 2019 - Mass Medical Soc
Key Clinical Points Obstructive Sleep Apnea in Adults Obstructive sleep apnea is common
and is an independent risk factor for motor vehicle accidents and cardiovascular disease …

[HTML][HTML] European Respiratory Society guideline on non-CPAP therapies for obstructive sleep apnoea

W Randerath, J Verbraecken… - European …, 2021 - Eur Respiratory Soc
Treatment of obstructive sleep apnoea (OSA) in adults is evolving, as new therapies have
been explored and introduced in clinical practice, while other approaches have been refined …

Evaluation and management of adults with obstructive sleep apnea syndrome

JJ Lee, KM Sundar - Lung, 2021 - Springer
Obstructive sleep apnea syndrome (OSAS) is a common and underdiagnosed medical
condition characterized by recurrent sleep-dependent pauses and reductions in airflow …

Obstructive sleep apnea: transition from pathophysiology to an integrative disease model

WT McNicholas, D Pevernagie - Journal of sleep research, 2022 - Wiley Online Library
Obstructive sleep apnea (OSA) is characterised by recurring episodes of upper airway
obstruction during sleep and the fundamental abnormality reflects the inability of the upper …

International consensus statement on obstructive sleep apnea

JL Chang, AN Goldberg, JA Alt… - International forum of …, 2023 - Wiley Online Library
Background Evaluation and interpretation of the literature on obstructive sleep apnea (OSA)
allows for consolidation and determination of the key factors important for clinical …

Molecular pathology, oxidative stress, and biomarkers in obstructive sleep apnea

PG Meliante, F Zoccali, F Cascone… - International Journal of …, 2023 - mdpi.com
Obstructive sleep apnea syndrome (OSAS) is characterized by intermittent hypoxia (IH)
during sleep due to recurrent upper airway obstruction. The derived oxidative stress (OS) …

A randomized controlled clinical trial exploring safety and tolerability of sulthiame in sleep apnea

J Hedner, K Stenlöf, D Zou, E Hoff… - American journal of …, 2022 - atsjournals.org
Rationale: Current therapies for obstructive sleep apnea (OSA) are limited by insufficient
efficacy, compliance, or tolerability. An effective pharmacological treatment for OSA is …

The noradrenergic agent reboxetine plus the antimuscarinic hyoscine butylbromide reduces sleep apnoea severity: A double‐blind, placebo‐controlled, randomised …

R Lim, L Messineo, RR Grunstein… - The Journal of …, 2021 - Wiley Online Library
Key points Recent animal and human physiology studies indicate that noradrenergic and
muscarinic processes are key mechanisms that mediate pharyngeal muscle control during …