Cellular plasticity is a well-known dynamic feature of tumor cells that endows tumors with
heterogeneity and therapeutic resistance and alters their invasion–metastasis progression …

Simple Summary Conventional antitumor drugs have limitations, including poor water
solubility and lack of targeting capability, with consequent non-specific distribution, systemic …

Therapy resistance is the primary problem in treating late-stage colorectal cancer (CRC).
Claudins are frequently dysregulated in cancer, and several are being investigated as novel …

Background Hyaluronic acid (HA) promotes cancer metastasis; however, the currently
approved treatments do not target HA. Metastatic renal carcinoma (mRCC) is an incurable …

Background: Deubiquitinating enzymes specifically removes ubiquitin molecules from
ubiquitin-tagged target proteins, thereby inhibiting the degradation of target proteins and …

Protein isoforms, generated through alternative splicing or promoter usage, contribute to
tissue function. Here, we characterize the expression of predicted Padi3α and Padi3β …

Alternative splicing is often deregulated in cancer, and cancer-specific isoform switches are
part of the oncogenic transformation of cells. Accumulating evidence indicates that isoforms …

Epithelial-mesenchymal transition (EMT) is a crucial process with significance in the
metastasis of malignant tumors. It is through the acquisition of plasticity that cancer cells …

Lenvatinib (LVN) has been appoved to treat advanced renal cell carcinoma, differentiated
thyroid carcinoma, hepatocellular carcinoma. Further other cancer types also have been …

Stemness and epithelial–mesenchymal plasticity are widely studied in the circulating tumor
cells of breast cancer patients because the roles of both processes in tumor progression are …