Intellectual disabilities (IDs) and autism spectrum disorders link to human APC inactivating
gene mutations. However, little is known about adenomatous polyposis coli's (APC's) role in …

The Wnt signaling pathway plays an important role in developmental processes, including
embryonic patterning, cell specification, and cell polarity. Wnt components participate in the …

The telomerase reverse transcriptase protein, TERT, is expressed in the adult brain and its
exogenic expression protects neurons from oxidative stress and from the cytotoxicity of …

Low bone mineral density (BMD) is a significant comorbidity in Alzheimer's disease (AD)
and may reflect systemic regulatory pathway dysfunction. Low BMD has been identified in …

In Alzheimer´ s disease (AD) there is a reduction in hippocampal neurogenesis that has
been associated to cognitive deficits. Previously we showed that Andrographolide (ANDRO) …

Alzheimer's disease (AD) is the most common type of dementia with an insidious onset and
slow progression. Kai-Xin-San (KXS) has been reported to be effective in improving …

Alzheimer's disease (AD) is a neurodegenerative disease, where the etiology remains
unclear. AD is characterized by amyloid-(Aβ) protein aggregation and neurofibrillary …

Synapse dysfunction and loss represent critical early events in the pathophysiology of
Alzheimer's disease (AD). While extensive research has elucidated the direct synaptotoxic …

Alzheimer's disease (AD) is the most common neurodegenerative disorder with the majority
of patients classified as sporadic AD (sAD), in which etiopathogenesis remains unresolved …

Cognitive decline is a cardinal feature of Alzheimer's disease (AD) predominantly linked to
synaptic failure, disrupted network connectivity and neurodegeneration. A large body of …