Parkinson's disease, aging and adult neurogenesis: Wnt/β‐catenin signalling as the key to unlock the mystery of endogenous brain repair

B Marchetti, C Tirolo, F L'Episcopo, S Caniglia… - Aging cell, 2020 - Wiley Online Library
A common hallmark of age‐dependent neurodegenerative diseases is an impairment of
adult neurogenesis. Wingless‐type mouse mammary tumor virus integration site (Wnt)/β …

New insights for oxidative stress and diabetes mellitus

K Maiese - Oxidative medicine and cellular longevity, 2015 - Wiley Online Library
The release of reactive oxygen species (ROS) and the generation of oxidative stress are
considered critical factors for the pathogenesis of diabetes mellitus (DM), a disorder that is …

Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders

K Maiese - British journal of clinical pharmacology, 2016 - Wiley Online Library
Neurodegenerative disorders are significantly increasing in incidence as the age of the
global population continues to climb with improved life expectancy. At present, more than 30 …

Wnt signaling activates TP53-induced glycolysis and apoptosis regulator and protects against cisplatin-induced spiral ganglion neuron damage in the mouse cochlea

W Liu, X Xu, Z Fan, G Sun, Y Han, D Zhang… - Antioxidants & redox …, 2019 - liebertpub.com
Aims: Cisplatin can damage spiral ganglion neurons (SGNs) and cause sensorineural
hearing loss. Wnt activation protects against neomycin-induced hair cell damage in the …

Wnt/β-catenin signaling pathway governs a full program for dopaminergic neuron survival, neurorescue and regeneration in the MPTP mouse model of Parkinson's …

B Marchetti - International journal of molecular sciences, 2018 - mdpi.com
Wingless-type mouse mammary tumor virus (MMTV) integration site (Wnt) signaling is one of
the most critical pathways in developing and adult tissues. In the brain, Wnt signaling …

Autophagy in diabetic retinopathy

M Di Rosa, G Distefano, C Gagliano… - Current …, 2016 - ingentaconnect.com
Autophagy is an important homeostatic cellular process encompassing a number of
consecutive steps indispensable for degrading and recycling cytoplasmic materials …

Wnt signaling pathway in cardiac fibrosis: New insights and directions

H Tao, JJ Yang, KH Shi, J Li - Metabolism, 2016 - Elsevier
Objective Wnt signaling pathway significantly participates in cardiac fibrosis and CFs
activation. Therefore, we reviewed current evidence on the new perspectives and biological …

Cellular metabolism: A fundamental component of degeneration in the nervous system

K Maiese - Biomolecules, 2023 - mdpi.com
It is estimated that, at minimum, 500 million individuals suffer from cellular metabolic
dysfunction, such as diabetes mellitus (DM), throughout the world. Even more concerning is …

Cognitive impairment and dementia: gaining insight through circadian clock gene pathways

K Maiese - Biomolecules, 2021 - mdpi.com
Neurodegenerative disorders affect fifteen percent of the world's population and pose a
significant financial burden to all nations. Cognitive impairment is the seventh leading cause …

[HTML][HTML] Neurodegeneration, memory loss, and dementia: the impact of biological clocks and circadian rhythm

K Maiese - Frontiers in bioscience (Landmark edition), 2021 - ncbi.nlm.nih.gov
Methods and results: Novel work with biological clock genes that oversee circadian rhythm
may meet this critical need by focusing upon the pathways of the mechanistic target of …