Intestinal barrier integrity is a prerequisite for homeostasis of mucosal function, which is
balanced to maximise absorptive capacity, while maintaining efficient defensive reactions …

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that form a family of
24 members in mammals. Evidence of the pathological roles of MMPs in various diseases …

Colorectal cancers (CRCs) deficient in DNA mismatch repair (dMMR) contain abundant
CD8+ tumor-infiltrating lymphocytes (TILs) responding to the abundant neoantigens from …

Chronic diseases confer tissue and organ damage that reduce quality of life and are largely
refractory to therapy. Although stem cells hold promise for treating degenerative diseases …

Inflammatory bowel diseases (IBDs), including Crohn's disease and ulcerative colitis are
complex disorders with undetermined etiology. Several hypotheses suggest that IBDs result …

Macrophages (mϕ) are essential for intestinal homeostasis and the pathology of
inflammatory bowel disease (IBD), but it is unclear whether discrete mϕ populations carry …

Recent studies have identified mucosal healing on endoscopy as a key prognostic
parameter in the management of inflammatory bowel diseases (IBD), thus highlighting the …

The mammalian intestine is colonized by over a trillion microbes that comprise the “gut
microbiota,” a microbial community which has co-evolved with the host to form a mutually …

Certain macrophage phenotypes contribute to tissue fibrosis, but why? Tissues host resident
mononuclear phagocytes for their support to maintain homeostasis. Upon injury the …

Lactobacilli have been shown to promote health functions. In this study, we analyzed the
mechanism by which four different strains of probiotics affected innate immunity, such as …