Osteochondral defects are caused by injury to both the articular cartilage and subchondral
bone within skeletal joints. They can lead to irreversible joint damage and increase the risk …

Osteochondral (OC) repair is an extremely challenging topic due to the complex biphasic
structure and poor intrinsic regenerative capability of natural osteochondral tissue. In …

The fabrication of biomimetic tracheas with a architecture of cartilaginous rings alternately
interspersed between vascularized fibrous tissue (CRVFT) has the potential to perfectly …

Hydrogels have been extensively favored as drug and cell carriers for the repair of knee
cartilage defects. Recruiting mesenchymal stem cells (MSCs) in situ to the defect region …

Tissue engineering (TE) is a therapeutic option within regenerative medicine that allows to
mimic the original cell environment and functional organization of the cell types necessary …

Hard tissues, eg, bone, are mechanically stiff and, most typically, mineralized. To design
scaffolds for hard tissue regeneration, mechanical, physico-chemical and biological cues …

The osteochondral (OC) unit plays a pivotal role in joint lubrication and in the transmission of
constraints to bones during movement. The OC unit does not spontaneously heal; therefore …

Osteochondral defects pose an enormous challenge due to the lack of an effective repair
strategy. To tackle this issue, the importance of a calcified cartilage interlayer (CCL) in …

The development of biomimetic scaffolds containing cartilage, calcified cartilage, and bone
regeneration for precise osteochondral repair remains a challenge. Herein, a novel tri …

Tissue engineering is rapidly progressing toward clinical application. In the musculoskeletal
field, there has been an increasing necessity for bone and cartilage replacement. Despite …