Persistent hair loss is a major cause of psychological distress and compromised quality of
life in millions of people worldwide. Remarkable progress has been made in understanding …

Sesquiterpene lactones, a vast range of terpenoids isolated from Asteraceae species,
exhibit a broad spectrum of biological effects and several of them are already commercially …

The cyclization of farnesyl diphosphate (FPP) into highly strained polycyclic sesquiterpenes
is challenging. We here determined the crystal structures of three sesquiterpene synthases …

The NLRP3 inflammasome's core and most specific protein, NLRP3, has a variety of
functions in inflammation-driven diseases. Costunolide (COS) is the major active ingredient …

Since ancient times, plant roots have been widely used in traditional medicine for treating
various ailments and diseases due to their beneficial effects. A large number of studies have …

The α‐methylene‐γ‐butyrolactone motif is a widely encountered unit in many natural
products and pharmaceutical compounds. Herein, a practical and efficient synthesis of α …

The development of bacterial resistance to antibiotics and the consequent lack of effective
therapy is one of the biggest problems in modern medicine. A consequence of these …

The surge of scientific interest in the discovery of Nuclear Factor Erythroid 2 (NFE2)-Related
Factor 2 (NRF2)-activating molecules underscores the importance of NRF2 as a therapeutic …

Doxorubicin (Dox) induces senescence in numerous cancer cell types, but these senescent
cancer cells relapse again if they are not eliminated. On this principle, we investigated the …

Doxorubicin (DOX), a common chemotherapeutic agent, suffers serious adverse effects
including hepatotoxicity. Mokko lactone (ML) is a guainolide sesquiterpene with promising …