As an ancient infectious disease, tuberculosis (TB) is still the leading cause of death from a
single infectious agent worldwide. Latent TB infection (LTBI) has been recognized as the …

The interaction of bacterial pathogens with mammalian hosts leads to a variety of
physiological responses of the interacting partners aimed at an adaptation to the new …

To elucidate the little-known bioenergetic pathways of host immune cells in tuberculosis, a
granulomatous disease caused by the intracellular pathogen Mycobacterium tuberculosis …

Infection by the intracellular bacterial pathogen Mycobacterium tuberculosis (Mtb) is a major
cause of morbidity and mortality worldwide. Slow progress has been made in lessening the …

We aimed to characterize metabolites during tuberculosis (TB) disease and identify new
pathophysiologic pathways involved in infection as well as biomarkers of TB onset …

Metabolism underpins the physiology and pathogenesis of Mycobacterium tuberculosis.
However, although experimental mycobacteriology has provided key insights into the …

Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful analytical platform
employed to address a diversity of issues of research such as in understanding chemical …

Mycobacterium tuberculosis infection, which claims hundreds of thousands of lives each
year, is typically characterized by the formation of tuberculous granulomas—the …

Alcohol-induced liver disease (ALD) is a leading cause of non-accident-related deaths in the
world. Identification of an early specific signature of ALD would aid in therapeutic …

The mechanisms whereby Mycobacterium tuberculosis (Mtb) rewires the host metabolism in
vivo are surprisingly unexplored. Here, we used three high-resolution mass spectrometry …