Single-cell RNA sequencing (scRNA-seq) identifies cell subpopulations within tissue but
does not capture their spatial distribution nor reveal local networks of intercellular …

Rare diseases affect 30 million people in the USA and more than 300–400 million
worldwide, often causing chronic illness, disability, and premature death. Traditional …

The novel SARS‐coronavirus 2 (SARS‐CoV‐2) poses a global challenge on healthcare and
society. For understanding the susceptibility for SARS‐CoV‐2 infection, the cell type‐specific …

The immunosuppressive status of the tumor microenvironment (TME) remains poorly
defined due to a lack of understanding regarding the function of tumor-associated …

MicroRNAs (miRNAs) are small non-coding RNAs with the capability of modulating gene
expression at the post-transcriptional level either by inhibiting messenger RNA (mRNA) …

Simple Summary Next-generation sequencing (NGS) is a powerful tool used in genomics
research. NGS can sequence millions of DNA fragments at once, providing detailed …

Advances in molecular biology, microfluidics and bioinformatics have empowered the study
of thousands or even millions of individual cells from malignant tumours at the single-cell …

Background: Ascending thoracic aortic aneurysm (ATAA) is caused by the progressive
weakening and dilatation of the aortic wall and can lead to aortic dissection, rupture, and …

Anti-angiogenic therapies (AATs) are used to treat different types of cancers. However, their
success is limited owing to insufficient efficacy and resistance. Recently, single-cell omics …

High‐throughput droplet‐based digital PCR (ddPCR) is a refinement of the conventional
polymerase chain reaction (PCR)‎ methods. In ddPCR, DNA/RNA is encapsulated …