Immunosenescence: molecular mechanisms and diseases
Z Liu, Q Liang, Y Ren, C Guo, X Ge, L Wang… - Signal transduction and …, 2023 - nature.com
Infection susceptibility, poor vaccination efficacy, age-related disease onset, and neoplasms
are linked to innate and adaptive immune dysfunction that accompanies aging (known as …
are linked to innate and adaptive immune dysfunction that accompanies aging (known as …
Age and age-related diseases: role of inflammation triggers and cytokines
IM Rea, DS Gibson, V McGilligan… - Frontiers in …, 2018 - frontiersin.org
Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …
system at older age, with evidence pointing to an inability to fine-control systemic …
Contributions of age-related thymic involution to immunosenescence and inflammaging
R Thomas, W Wang, DM Su - Immunity & Ageing, 2020 - Springer
Immune system aging is characterized by the paradox of immunosenescence (insufficiency)
and inflammaging (over-reaction), which incorporate two sides of the same coin, resulting in …
and inflammaging (over-reaction), which incorporate two sides of the same coin, resulting in …
Inflammation–nature's way to efficiently respond to all types of challenges: implications for understanding and managing “the epidemic” of chronic diseases
Siloed or singular system approach to disease management is common practice,
developing out of traditional medical school education. Textbooks of medicine describe a …
developing out of traditional medical school education. Textbooks of medicine describe a …
Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases
C Franceschi, J Campisi - Journals of Gerontology Series A …, 2014 - academic.oup.com
Human aging is characterized by a chronic, low-grade inflammation, and this phenomenon
has been termed as “inflammaging.” Inflammaging is a highly significant risk factor for both …
has been termed as “inflammaging.” Inflammaging is a highly significant risk factor for both …
T cell regeneration after immunological injury
Following periods of haematopoietic cell stress, such as after chemotherapy, radiotherapy,
infection and transplantation, patient outcomes are linked to the degree of immune …
infection and transplantation, patient outcomes are linked to the degree of immune …
Aging, cellular senescence, and cancer
J Campisi - Annual review of physiology, 2013 - annualreviews.org
For most species, aging promotes a host of degenerative pathologies that are characterized
by debilitating losses of tissue or cellular function. However, especially among vertebrates …
by debilitating losses of tissue or cellular function. However, especially among vertebrates …
Immunosenescence, inflammaging, and frailty: role of myeloid cells in age-related diseases
A Bleve, F Motta, B Durante, C Pandolfo… - Clinical reviews in …, 2022 - Springer
The immune system is the central regulator of tissue homeostasis, ensuring tissue
regeneration and protection against both pathogens and the neoformation of cancer cells. Its …
regeneration and protection against both pathogens and the neoformation of cancer cells. Its …
Effects of ageing on the immune system: infants to elderly
R Valiathan, M Ashman… - Scandinavian journal of …, 2016 - Wiley Online Library
Physiological ageing is accompanied by decline in immune system function and immune
alteration during ageing increases susceptibility to infections. We retrospectively analysed …
alteration during ageing increases susceptibility to infections. We retrospectively analysed …
Sestrins induce natural killer function in senescent-like CD8+ T cells
BI Pereira, RPH De Maeyer, LP Covre… - Nature …, 2020 - nature.com
Aging is associated with remodeling of the immune system to enable the maintenance of life-
long immunity. In the CD8+ T cell compartment, aging results in the expansion of highly …
long immunity. In the CD8+ T cell compartment, aging results in the expansion of highly …