Infection susceptibility, poor vaccination efficacy, age-related disease onset, and neoplasms
are linked to innate and adaptive immune dysfunction that accompanies aging (known as …

Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …

Immune system aging is characterized by the paradox of immunosenescence (insufficiency)
and inflammaging (over-reaction), which incorporate two sides of the same coin, resulting in …

Siloed or singular system approach to disease management is common practice,
developing out of traditional medical school education. Textbooks of medicine describe a …

Human aging is characterized by a chronic, low-grade inflammation, and this phenomenon
has been termed as “inflammaging.” Inflammaging is a highly significant risk factor for both …

Following periods of haematopoietic cell stress, such as after chemotherapy, radiotherapy,
infection and transplantation, patient outcomes are linked to the degree of immune …

For most species, aging promotes a host of degenerative pathologies that are characterized
by debilitating losses of tissue or cellular function. However, especially among vertebrates …

The immune system is the central regulator of tissue homeostasis, ensuring tissue
regeneration and protection against both pathogens and the neoformation of cancer cells. Its …

Physiological ageing is accompanied by decline in immune system function and immune
alteration during ageing increases susceptibility to infections. We retrospectively analysed …

Aging is associated with remodeling of the immune system to enable the maintenance of life-
long immunity. In the CD8+ T cell compartment, aging results in the expansion of highly …