Extracellular matrix proteins form the basic structure of blood vessels. Along with providing
basic structural support to blood vessels, matrix proteins interact with different sets of …

Background Diabetic foot ulcer (DFU) is a severe complication of diabetes, preceding most
diabetes-related amputations. DFUs require over US $9 billion for yearly treatment and are …

A role for fibroblasts in physiological and pathological angiogenesis is now well recognized;
however, the precise mechanisms underlying their action have not been determined. Using …

The ability to differentiate human pluripotent stem cells into endothelial cells with properties
of cord-blood endothelial colony–forming cells (CB-ECFCs) may enable the derivation of …

Co-cultures of endothelial cells (EC) and mesenchymal stem cells (MSC) in three-
dimensional (3D) protein hydrogels can be used to recapitulate aspects of vasculogenesis …

Cell migration initiates by traction generation through reciprocal actomyosin tension and
focal adhesion reinforcement, but continued motility requires adaptive cytoskeletal …

The development of blood vessels, referred to as angiogenesis, is an intricate process
regulated spatially and temporally through a delicate balance between the qualitative and …

Functional and perfusable vascular network formation is critical to ensure the long-term
survival and functionality of engineered tissues after their transplantation. Although several …

Understanding the role of the extracellular matrix (ECM) in vascular morphogenesis has
been possible using natural ECMs as in vitro models to study the underlying molecular …

Repairing and rebuilding damaged tissue in diseased human subjects remains a daunting
challenge for clinical medicine. Proper vascular formation that serves to deliver blood-borne …