Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …

Purinergic signalling is involved in a number of physiological and pathophysiological
activities in the lower urinary tract. In the bladder of laboratory animals there is …

This article provides a synopsis of current progress made in fundamental studies of lower
urinary tract dysfunction (LUTD) after spinal cord injury (SCI) above the sacral level. Animal …

Background Sensory nerves innervating the airways play an important role in regulating
various cardiopulmonary functions, maintaining homeostasis under healthy conditions and …

The isolated bladder shows autonomous micromotions, which increase with bladder
distension, generate sensory nerve activity, and are altered in models of urinary dysfunction …

In the last decades, a number of new antimuscarinic drugs have been introduced for
treatment of the overactive bladder (OAB), defined symptomatically (OAB syndrome) or …

Painful sensations are some of the most frequent complaints of patients who are admitted to
local medical clinics. Persistent pain varies according to its causes, often resulting from local …

Background The pathophysiology of male lower urinary tract symptoms (LUTS) is highly
complex and multifactorial. The shift in perception that LUTS are not sex or organ specific …

Background Effective, well-tolerated novel treatments for overactive bladder (OAB) are
lacking. The P2X3 receptor antagonist eliapixant demonstrated potential to reduce OAB …

It is well established that in most species, exocytotic vesicular release of ATP from
parasympathetic neurons contributes to contraction of the bladder. However, ATP is …