Prostacyclin (PGI2) is a member of the prostanoid group of eicosanoids that regulate
homeostasis, hemostasis, smooth muscle function and inflammation. Prostanoids are …

Cyclooxygenases (COXs) oxidize arachidonic acid to prostaglandin (PG) G 2 and H 2
followed by PG synthases that generates PGs and thromboxane (TX) A 2. COXs are divided …

Neuroglial cells are fundamental for control of brain homeostasis and they represent the
intrinsic brain defence system. All forms in neuropathology therefore inevitably involve glia …

Three enzyme systems, cyclooxygenases that generate prostaglandins, lipoxygenases that
form hydroxy derivatives and leukotrienes, and epoxygenases that give rise to …

Recent breakthroughs in neuroscience have led to the awareness that we should revise our
traditional mode of thinking and studying the CNS, ie by isolating the privileged network of …

Aging is an important risk factor for post-stroke infection, which accounts for a large
proportion of stroke-associated mortality. Despite this, studies evaluating post-stroke …

Post-ischemic inflammation is important in ischemic stroke pathology. However, details of
the inflammation process, its resolution after stroke and its effect on pathology and neural …

The restoration of energy balance during ischemia is critical to cellular survival; however,
relatively little is known concerning the regulation of neuronal metabolic pathways in …

The significance of the hypoxia component of stroke injury is highlighted by hypermetabolic
brain tissue enriched with arachidonic acid (AA), a 22: 6n-3 polyunsaturated fatty acid. In an …

Abstract Cyclooxygenase-2 (COX-2), a rate-limiting enzyme for prostanoid synthesis, has
been implicated in the neurotoxicity resulting from hypoxia-ischemia, and its inhibition has …