Cilia sense and transduce sensory stimuli, homeostatic cues and developmental signals by
orchestrating signaling reactions. Extracellular vesicles (EVs) that bud from the ciliary …

Primary cilia act as cell surface antennae, coordinating cellular responses to sensory inputs
and signalling molecules that regulate developmental and homeostatic pathways. Cilia are …

Cilia are sensory organelles protruding from cell surfaces. Release of extracellular vesicles
(EVs) from cilia was previously observed in mammals, Chlamydomonas, and in male …

Ciliary extracellular vesicle (EV) shedding is evolutionarily conserved. In Chlamydomonas
and C. elegans, ciliary EVs act as signaling devices. 1–3 In cultured mammalian cells, ciliary …

Primary cilia are microtubule based sensory organelles important for receiving and
processing cellular signals. Recent studies have shown that cilia also release extracellular …

Many G protein-coupled receptors (GPCRs) reside within cilia of mammalian cells and must
undergo regulated exit from cilia for the appropriate transduction of signals such as …

Cilia both receive and send information, the latter in the form of extracellular vesicles (EVs).
EVs are nano-communication devices that influence cell, tissue, and organism behavior …

The primary cilium is a microtubule-based organelle that extends from a basal body at the
surface of most cells. This antenna is an efficient sensor of the cell micro-environment and is …

Rab and Arl guanine nucleotidebinding (G) proteins regulate trafficking pathways essential
for the formation, function and composition of primary cilia, which are sensory devices …

The ARF family of regulatory GTPases is ancient, with 16 members predicted to have been
present in the last eukaryotic common ancestor. Our phylogenetic profiling of paralogues in …