CD4+ T cells in cancer
Cancer immunology and immunotherapy are driving forces of research and development in
oncology, mostly focusing on CD8+ T cells and the tumor microenvironment. Recent …
oncology, mostly focusing on CD8+ T cells and the tumor microenvironment. Recent …
Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy
L Yang, Z Chu, M Liu, Q Zou, J Li, Q Liu… - Journal of hematology & …, 2023 - Springer
Amino acids are basic nutrients for immune cells during organ development, tissue
homeostasis, and the immune response. Regarding metabolic reprogramming in the tumor …
homeostasis, and the immune response. Regarding metabolic reprogramming in the tumor …
Increased memory B cell potency and breadth after a SARS-CoV-2 mRNA boost
The Omicron variant of SARS-CoV-2 infected many vaccinated and convalescent
individuals,–. Despite the reduced protection from infection, individuals who received three …
individuals,–. Despite the reduced protection from infection, individuals who received three …
Efficient evolution of human antibodies from general protein language models
Natural evolution must explore a vast landscape of possible sequences for desirable yet
rare mutations, suggesting that learning from natural evolutionary strategies could guide …
rare mutations, suggesting that learning from natural evolutionary strategies could guide …
Three exposures to the spike protein of SARS-CoV-2 by either infection or vaccination elicit superior neutralizing immunity to all variants of concern
PR Wratil, M Stern, A Priller, A Willmann, G Almanzar… - Nature medicine, 2022 - nature.com
Infection-neutralizing antibody responses after severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection or coronavirus disease 2019 vaccination are an …
coronavirus 2 (SARS-CoV-2) infection or coronavirus disease 2019 vaccination are an …
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses
Adjuvants are critical for improving the quality and magnitude of adaptive immune
responses to vaccination. Lipid nanoparticle (LNP)-encapsulated nucleoside-modified …
responses to vaccination. Lipid nanoparticle (LNP)-encapsulated nucleoside-modified …
Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection
More than one year after its inception, the coronavirus disease 2019 (COVID-19) pandemic
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains difficult …
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains difficult …
Germinal centre-driven maturation of B cell response to mRNA vaccination
Germinal centres (GC) are lymphoid structures in which B cells acquire affinity-enhancing
somatic hypermutations (SHM), with surviving clones differentiating into memory B cells …
somatic hypermutations (SHM), with surviving clones differentiating into memory B cells …
Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection produces B cell
responses that continue to evolve for at least a year. During that time, memory B cells …
responses that continue to evolve for at least a year. During that time, memory B cells …
[HTML][HTML] Evolution of antibody immunity to SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected 78 million
individuals and is responsible for over 1.7 million deaths to date. Infection is associated with …
individuals and is responsible for over 1.7 million deaths to date. Infection is associated with …