Social circuits and their dysfunction in autism spectrum disorder
Social behaviors, how individuals act cooperatively and competitively with conspecifics, are
widely seen across species. Rodents display various social behaviors, and many different …
widely seen across species. Rodents display various social behaviors, and many different …
The synaptic and circuit functions of vitamin D in neurodevelopment disorders
X Ye, Q Zhou, P Ren, W Xiang… - … Disease and Treatment, 2023 - Taylor & Francis
Vitamin D deficiency/insufficiency is a public health issue around the world. According to
epidemiological studies, low vitamin D levels have been associated with an increased risk of …
epidemiological studies, low vitamin D levels have been associated with an increased risk of …
Sexual dimorphism in the social behaviour of Cntnap2-null mice correlates with disrupted synaptic connectivity and increased microglial activity in the anterior …
MS Dawson, K Gordon-Fleet, L Yan, V Tardos… - Communications …, 2023 - nature.com
A biological understanding of the apparent sex bias in autism is lacking. Here we have
identified Cntnap2 KO mice as a model system to help better understand this dimorphism …
identified Cntnap2 KO mice as a model system to help better understand this dimorphism …
Cntnap2-dependent molecular networks in autism spectrum disorder revealed through an integrative multi-omics analysis
Autism spectrum disorder (ASD) is a major neurodevelopmental disorder in which patients
present with core symptoms of social communication impairment, restricted interest, and …
present with core symptoms of social communication impairment, restricted interest, and …
Oxytocin neurons mediate stress-induced social memory impairment
Oxytocin has long been thought to play a substantial role in social behaviors, such as social
attachment and parenting behavior. However, how oxytocin neurons respond to social and …
attachment and parenting behavior. However, how oxytocin neurons respond to social and …
Impaired emotion recognition in Cntnap2-deficient mice is associated with hyper-synchronous prefrontal cortex neuronal activity
AN Mohapatra, R Jabarin, N Ray, S Netser… - Molecular …, 2024 - nature.com
Individuals diagnosed with autism spectrum disorder (ASD) show difficulty in recognizing
emotions in others, a process termed emotion recognition. While human fMRI studies linked …
emotions in others, a process termed emotion recognition. While human fMRI studies linked …
[HTML][HTML] Balance between projecting neuronal populations of the nucleus accumbens controls social behavior in mice
J Le Merrer, B Detraux, J Gandía, A De Groote… - Biological …, 2024 - Elsevier
Background Deficient social interactions are a hallmark of major neuropsychiatric disorders,
and accumulating evidence points to altered social reward and motivation as key underlying …
and accumulating evidence points to altered social reward and motivation as key underlying …
[HTML][HTML] Somatosensory cortex hyperconnectivity and impaired whisker-dependent responses in Cntnap2−/− mice
Sensory abnormalities are a common feature in autism spectrum disorders (ASDs). Tactile
responsiveness is altered in autistic individuals, with hypo-responsiveness being associated …
responsiveness is altered in autistic individuals, with hypo-responsiveness being associated …
The impact of Microglia on Neurodevelopment and Brain function in Autism
Y Luo, Z Wang - Biomedicines, 2024 - mdpi.com
Microglia, as one of the main types of glial cells in the central nervous system (CNS), are
widely distributed throughout the brain and spinal cord. The normal number and function of …
widely distributed throughout the brain and spinal cord. The normal number and function of …
A comprehensive assay of social motivation reveals sex-specific roles of autism-associated genes and oxytocin
SE Maloney, S Sarafinovska, C Weichselbaum… - Cell reports …, 2023 - cell.com
Social motivation is critical to the development of typical social functioning. Social
motivation, specifically one or more of its components (eg, social reward seeking or social …
motivation, specifically one or more of its components (eg, social reward seeking or social …