Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …

The discovery of cannabinoid receptors and subsequent identification of their endogenous
ligands (endocannabinoids) in early 1990s have greatly accelerated research on …

The recent identification of cannabinoid receptors and their endogenous lipid ligands has
triggered an exponential growth of studies exploring the endocannabinoid system and its …

In this review we will critically assess the hypothesis that the reinforcing effect of virtually all
drugs of abuse is primarily dependent on activation of the mesolimbic dopamine system …

Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

Background The widespread use of cannabis, the increasing legalization of “medical”
cannabis, the increasing potency of cannabis, and the growing recreational use of synthetic …

Given the rise in teenage use of electronic nicotine delivery systems (“vaping”) in
congruence with the increasing numbers of drug-related emergencies, it is critical to expand …

Substance use disorder is characterized by repeated use of a substance, leading to
clinically significant distress, making it a serious public health concern. The …

Δ9-Tetrahydrocannabinol from Cannabis sativa is mimicked by cannabimimetic analogs
such as CP55940 and WIN55212-2, and antagonized by rimonabant and SR144528 …

Recent studies have shown that the endocannabinoid system is involved in the common
neurobiological mechanism underlying drug addiction. This system participates in the …