Septins are an integral component of the cytoskeleton, assembling into higher-order
oligomers and filamentous polymers that associate with actin filaments, microtubules and …

In order to fully understand any complex biochemical system from a mechanistic point of
view, it is necessary to have access to the three-dimensional structures of the molecular …

Vascular smooth muscle (VSM) plays an important role in the regulation of vascular function.
Identifying the mechanisms of VSM contraction has been a major research goal in order to …

As germ cells progress through spermatogenesis, they undergo a dramatic transformation,
wherein a single, diploid spermatogonial stem cell ultimately produces thousands of highly …

In the almost 70 years since the first hints of its existence, the phosphoinositide,
phosphatidyl-D-myo-inositol 4, 5-bisphosphate has been found to be central in the …

Septins are GTP binding proteins considered to be novel components of the cytoskeleton.
They polymerize into filaments based on hexameric or octameric core particles in which two …

Septin GTPases form nonpolar heteropolymers that play important roles in cytokinesis and
other cellular processes. The ability to form heteropolymers appears to be critical to many …

Primary cilia are antenna‐like organelles required for signalling transduction. How cilia
structure is mechanistically maintained at steady‐state to promote signalling is largely …

Osteoclasts are giant multinucleated myeloid cells specialized for bone resorption, which is
essential for the preservation of bone health throughout life. The activity of osteoclasts relies …

Chronic inflammatory diseases cause profound alterations in tissue homeostasis, including
unchecked activation of immune and nonimmune cells leading to disease complications …