Vitamin C has been known for decades. It is common in everyday use as an element of the
diet, supplementation, and a preservative. For years, research has been conducted to …

Carcinomas are phenotypically arrayed along an epithelial–mesenchymal transition (EMT)
spectrum, a developmental program currently exploited to understand the acquisition of drug …

Summary Cyclin-dependent kinase 9 (CDK9) promotes transcriptional elongation through
RNAPII pause release. We now report that CDK9 is also essential for maintaining gene …

hydroxymethylcytosine (5hmC) is a DNA base created during active DNA demethylation by
the recently discovered TET enzymes. 5hmC has essential roles in gene expression and …

Gastric cancer is the second leading cause of cancer-related death worldwide. RNA
nanotechnology has recently emerged as an important field due to recent finding of its high …

Current treatment of intrahepatic cholangiocarcinoma (ICC) remains ineffective because
knowledge of ICC carcinogenesis is unclear. Increasing evidence suggests that microRNAs …

Micronutrients such as vitamins and trace elements are crucial for maintaining the health of
all organisms. Micronutrients are involved in every cellular/biochemical process. They play …

The role of transcriptional regulator ten-eleven translocation methylcytosine dioxygenease 1
(TET1) has not been well characterized in lung cancer. Here we show that TET1 is …

The classical oxidizing enzymatic activity of Ten Eleven Translocation 1 (TET1) and its tumor
suppressor role are well known. Here, we find that high TET1 expression is associated with …

Oncogene-induced DNA methylation-mediated transcriptional silencing of tumor
suppressors frequently occurs in cancer, but the mechanism and functional role of this …