[HTML][HTML] Multimeric G-quadruplexes: A review on their biological roles and targeting
In human cells, nucleic acids adopt several non-canonical structures that regulate key
cellular processes. Among them, G-quadruplexes (G4s) are stable structures that form in …
cellular processes. Among them, G-quadruplexes (G4s) are stable structures that form in …
G-quadruplexes in neurobiology and virology: functional roles and potential therapeutic approaches
A G-quadruplex (G4) is a four-stranded nucleic acid secondary structure maintained by
Hoogsteen hydrogen bonds established between four guanines. Experimental studies and …
Hoogsteen hydrogen bonds established between four guanines. Experimental studies and …
Genome-wide mapping of i-motifs reveals their association with transcription regulation in live human cells
I Zanin, E Ruggiero, G Nicoletto, S Lago… - Nucleic Acids …, 2023 - academic.oup.com
Abstract i-Motifs (iMs) are four-stranded DNA structures that form at cytosine (C)-rich
sequences in acidic conditions in vitro. Their formation in cells is still under debate. We …
sequences in acidic conditions in vitro. Their formation in cells is still under debate. We …
Normal and pathogenic variation of RFC1 repeat expansions: implications for clinical diagnosis
N Dominik, S Magri, R Currò, E Abati, S Facchini… - Brain, 2023 - academic.oup.com
Cerebellar ataxia, neuropathy and vestibular areflexia syndrome (CANVAS) is an autosomal
recessive neurodegenerative disease, usually caused by biallelic AAGGG repeat …
recessive neurodegenerative disease, usually caused by biallelic AAGGG repeat …
[HTML][HTML] Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs
S Seneff, G Nigh, AM Kyriakopoulos… - Food and Chemical …, 2022 - Elsevier
Abstract The mRNA SARS-CoV-2 vaccines were brought to market in response to the public
health crises of Covid-19. The utilization of mRNA vaccines in the context of infectious …
health crises of Covid-19. The utilization of mRNA vaccines in the context of infectious …
Ligand-induced native G-quadruplex stabilization impairs transcription initiation
C Li, H Wang, Z Yin, P Fang, R Xiao, Y Xiang… - Genome …, 2021 - genome.cshlp.org
G-quadruplexes (G4s) are noncanonical DNA secondary structures formed through the self-
association of guanines, and G4s are distributed widely across the genome. G4 participates …
association of guanines, and G4s are distributed widely across the genome. G4 participates …
Phen‐DC3 Induces Refolding of Human Telomeric DNA into a Chair‐Type Antiparallel G‐Quadruplex through Ligand Intercalation
A Ghosh, M Trajkovski… - Angewandte Chemie …, 2022 - Wiley Online Library
Human telomeric G‐quadruplex DNA structures are attractive anticancer drug targets, but
the target's polymorphism complicates the drug design: different ligands prefer different …
the target's polymorphism complicates the drug design: different ligands prefer different …
RNA G-quadruplex organizes stress granule assembly through DNAPTP6 in neurons
S Asamitsu, Y Yabuki, K Matsuo, M Kawasaki… - Science …, 2023 - science.org
Consecutive guanine RNA sequences can adopt quadruple-stranded structures, termed
RNA G-quadruplexes (rG4s). Although rG4-forming sequences are abundant in …
RNA G-quadruplexes (rG4s). Although rG4-forming sequences are abundant in …
Peptides selected by G4-mRNA display-seq enable RNA G-quadruplex recognition and gene regulation
G-quadruplexes (G4s) are noncanonical secondary structures that play critical roles in both
chemistry and biology. Although several approaches have been developed for G4 targeting …
chemistry and biology. Although several approaches have been developed for G4 targeting …
[HTML][HTML] Structural insight into the bulge-containing KRAS oncogene promoter G-quadruplex bound to berberine and coptisine
KB Wang, Y Liu, J Li, C Xiao, Y Wang, W Gu… - Nature …, 2022 - nature.com
KRAS is one of the most highly mutated oncoproteins, which is overexpressed in various
human cancers and implicated in poor survival. The G-quadruplex formed in KRAS …
human cancers and implicated in poor survival. The G-quadruplex formed in KRAS …