In human cells, nucleic acids adopt several non-canonical structures that regulate key
cellular processes. Among them, G-quadruplexes (G4s) are stable structures that form in …

A G-quadruplex (G4) is a four-stranded nucleic acid secondary structure maintained by
Hoogsteen hydrogen bonds established between four guanines. Experimental studies and …

Abstract i-Motifs (iMs) are four-stranded DNA structures that form at cytosine (C)-rich
sequences in acidic conditions in vitro. Their formation in cells is still under debate. We …

Cerebellar ataxia, neuropathy and vestibular areflexia syndrome (CANVAS) is an autosomal
recessive neurodegenerative disease, usually caused by biallelic AAGGG repeat …

Abstract The mRNA SARS-CoV-2 vaccines were brought to market in response to the public
health crises of Covid-19. The utilization of mRNA vaccines in the context of infectious …

G-quadruplexes (G4s) are noncanonical DNA secondary structures formed through the self-
association of guanines, and G4s are distributed widely across the genome. G4 participates …

Human telomeric G‐quadruplex DNA structures are attractive anticancer drug targets, but
the target's polymorphism complicates the drug design: different ligands prefer different …

Consecutive guanine RNA sequences can adopt quadruple-stranded structures, termed
RNA G-quadruplexes (rG4s). Although rG4-forming sequences are abundant in …

G-quadruplexes (G4s) are noncanonical secondary structures that play critical roles in both
chemistry and biology. Although several approaches have been developed for G4 targeting …

KRAS is one of the most highly mutated oncoproteins, which is overexpressed in various
human cancers and implicated in poor survival. The G-quadruplex formed in KRAS …