[HTML][HTML] The role of sphingolipid signaling in oxidative lung injury and pathogenesis of bronchopulmonary dysplasia
JM Thomas, T Sudhadevi, P Basa, AW Ha… - International journal of …, 2022 - mdpi.com
Premature infants are born with developing lungs burdened by surfactant deficiency and a
dearth of antioxidant defense systems. Survival rate of such infants has significantly …
dearth of antioxidant defense systems. Survival rate of such infants has significantly …
[HTML][HTML] Krüppel-like factor 12 regulates aging ovarian granulosa cell apoptosis by repressing SPHK1 transcription and sphingosine-1-phosphate (S1P) production
CX Zhang, YL Lin, FF Lu, LN Yu, Y Liu, JD Zhou… - Journal of Biological …, 2023 - ASBMB
Oxidative stress triggered by aging, radiation, or inflammation impairs ovarian function by
inducing granulosa cell (GC) apoptosis. However, the mechanism inducing GC apoptosis …
inducing granulosa cell (GC) apoptosis. However, the mechanism inducing GC apoptosis …
[HTML][HTML] NOX4 mediates epithelial cell death in hyperoxic acute lung injury through mitochondrial reactive oxygen species
A Harijith, P Basa, A Ha, J Thomas, A Jafri… - Frontiers in …, 2022 - frontiersin.org
Management of acute respiratory distress involves O2 supplementation, which is lifesaving,
but causes severe hyperoxic acute lung injury (HALI). NADPH oxidase (NOX) could be a …
but causes severe hyperoxic acute lung injury (HALI). NADPH oxidase (NOX) could be a …
[HTML][HTML] Increased serum levels of proinflammatory cytokines are accompanied by fatigue in military T-6A Texan II instructor pilots
EG Damato, SJ Fillioe, SP Margevicius… - Frontiers in …, 2022 - frontiersin.org
Tactical aviation imposes unprecedented physical challenges including repetitive exposure
to hypergravity, hyperoxia, increased work of breathing, and profound cognitive workloads …
to hypergravity, hyperoxia, increased work of breathing, and profound cognitive workloads …
Sphingosine kinase 1-specific inhibitor PF543 reduces goblet cell metaplasia of bronchial epithelium in an acute asthma model
T Sudhadevi, SJ Ackerman, A Jafri… - … of Physiology-Lung …, 2024 - journals.physiology.org
Sphingosine kinase 1 (SPHK1) has been shown to play a key role in the pathogenesis of
asthma where SPHK1-generated sphingosine-1-phosphate (S1P) is known to mediate …
asthma where SPHK1-generated sphingosine-1-phosphate (S1P) is known to mediate …
[HTML][HTML] IRF4 affects the protective effect of regulatory T cells on the pulmonary vasculature of a bronchopulmonary dysplasia mouse model by regulating FOXP3
Y Zhu, L He, Y Zhu, H Yao, J Jiang, H Lu - Molecular Medicine, 2024 - Springer
Background Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in
preterm infants, characterised by compromised alveolar development and pulmonary …
preterm infants, characterised by compromised alveolar development and pulmonary …
[HTML][HTML] Serum sphingosine-1 phosphate level is increased in patients with hepatitis B and displays a positive association with liver fibrosis
M Sun, L Zeng, M Hu - American Journal of Translational Research, 2022 - ncbi.nlm.nih.gov
Objective: To investigate the difference in serum sphingosine-1 phosphate (S1P)
concentration between the HBV hepatitis patients and healthy controls, and its relevant …
concentration between the HBV hepatitis patients and healthy controls, and its relevant …