Blood reflects tissue oxidative stress depending on biomarker and tissue studied

AS Veskoukis, MG Nikolaidis, A Kyparos… - Free Radical Biology and …, 2009 - Elsevier
This study investigated whether selected oxidative stress markers measured in blood
adequately reflect redox status in skeletal muscle, heart, and liver. Several markers were …

Plasma oxidative stress parameters in men and women with early stage Alzheimer type dementia

MC Puertas, JM Martinez-Martos, MP Cobo… - Experimental …, 2012 - Elsevier
It is well known that oxidative stress is one of the earliest events in Alzheimer's disease
pathogenesis, indicating that may play a key role in this disease. In our study, we measured …

Glutathione relates to neuropsychological functioning in mild cognitive impairment

SL Duffy, J Lagopoulos, IB Hickie, K Diamond… - Alzheimer's & …, 2014 - Elsevier
Background Mild cognitive impairment (MCI) represents an at-risk state for Alzheimer's
disease in which underlying pathophysiological mechanisms could be delineated. Oxidative …

S-glutathionylation and S-nitrosylation in mitochondria: Focus on homeostasis and neurodegenerative diseases

S Vrettou, B Wirth - International Journal of Molecular Sciences, 2022 - mdpi.com
Redox post-translational modifications are derived from fluctuations in the redox potential
and modulate protein function, localization, activity and structure. Amongst the oxidative …

[HTML][HTML] Effects of dietary food components on cognitive functions in older adults

H Ozawa, T Miyazawa, T Miyazawa - Nutrients, 2021 - mdpi.com
Population aging has recently been an important issue as the number of elderly people is
growing worldwide every year, and the extension of social security costs is financially costly …

Potentiation of glutathione loss and nerve cell death by the transition metals iron and copper: Implications for age-related neurodegenerative diseases

P Maher - Free Radical Biology and Medicine, 2018 - Elsevier
There is growing evidence for alterations in iron and copper homeostasis during aging that
are exacerbated in neurodegenerative diseases such as Alzheimer's disease (AD) …

Quantitation of in vivo brain glutathione conformers in cingulate cortex among age‐matched control, MCI, and AD patients using MEGA‐PRESS

D Shukla, PK Mandal, M Tripathi… - Human brain …, 2020 - Wiley Online Library
Oxidative stress (OS) plays an important role in Alzheimer's disease (AD) and glutathione
(GSH) mitigates this effect by maintaining redox‐imbalance and free‐radical neutralization …

Glutathione: an old and small molecule with great functions and new applications in the brain and in Alzheimer's disease

M Haddad, V Hervé, MR Ben Khedher… - Antioxidants & Redox …, 2021 - liebertpub.com
Significance: Glutathione (GSH) represents the most abundant and the main antioxidant in
the body with important functions in the brain related to Alzheimer's disease (AD). Recent …

Cognitive improvement with glutathione supplement in Alzheimer's disease: a way forward

PK Mandal, D Shukla, M Tripathi… - Journal of Alzheimer's …, 2019 - content.iospress.com
Alzheimer's disease (AD) is a devastating neurodegenerative disorder affecting millions of
people worldwide. The actual cause of AD is still unknown. Oxidative stress is believed to be …

Ferroptosis and neurodegenerative diseases: Insights into the regulatory roles of SLC7A11

C Wang, H Liu, S Xu, Y Deng, B Xu, T Yang… - Cellular and Molecular …, 2023 - Springer
Programed cell death plays a key role in promoting human development and maintaining
homeostasis. Ferroptosis is a recently identified pattern of programmed cell death that is …