Machine-learned analysis of the association of next-generation sequencing–based genotypes with persistent pain after breast cancer surgery

D Kringel, MA Kaunisto, E Kalso, J Loetsch - Pain, 2019 - journals.lww.com
Cancer and its surgical treatment are among the most important triggering events for
persistent pain, but additional factors need to be present for the clinical manifestation, such …

Machine-learned analysis of global and glial/opioid intersection–related DNA methylation in patients with persistent pain after breast cancer surgery

D Kringel, MA Kaunisto, E Kalso, J Lötsch - Clinical epigenetics, 2019 - Springer
Background Glial cells in the central nervous system play a key role in neuroinflammation
and subsequent central sensitization to pain. They are therefore involved in the …

Computational functional genomics-based AmpliSeq™ panel for next-generation sequencing of key genes of pain

D Kringel, S Malkusch, E Kalso, J Lötsch - International journal of …, 2021 - mdpi.com
The genetic background of pain is becoming increasingly well understood, which opens up
possibilities for predicting the individual risk of persistent pain and the use of tailored …

Linked paired strand sequencing

EN Glezer, MM Fabani, S Shore, D Witters - US Patent 11,359,238, 2022 - Google Patents
Provided herein are methods for sequencing both strands of a double stranded nucleic acid
fragment that improves fidelity and accuracy of a sequence determination compared to …

Linked paired strand sequencing

EN Glezer, MM Fabani, S Shore, D Witters - US Patent 11,519,029, 2022 - Google Patents
2022-09-06 Assigned to SINGULAR GENOMICS SYSTEMS, INC reassignment SINGULAR
GENOMICS SYSTEMS, INC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …

Linked paired strand sequencing

EN Glezer, MM Fabani, S Shore, D Witters - US Patent 11,365,445, 2022 - Google Patents
Provided herein are methods for sequencing both strands of a double stranded nucleic acid
fragment that improves fidelity and accuracy of a sequence determination compared to …

Linked paired strand sequencing

EN Glezer, MM Fabani, S Shore, D Witters - US Patent 11,891,660, 2024 - Google Patents
2022-11-29 Assigned to SINGULAR GENOMICS SYSTEMS, INC reassignment SINGULAR
GENOMICS SYSTEMS, INC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …