The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy

A Iorga, CM Cunningham, S Moazeni… - Biology of sex …, 2017 - Springer
Epidemiologic studies have previously suggested that premenopausal females have
reduced incidence of cardiovascular disease (CVD) when compared to age-matched males …

Mitochondria: a central target for sex differences in pathologies

R Ventura-Clapier, M Moulin, J Piquereau… - Clinical …, 2017 - portlandpress.com
It is increasingly acknowledged that a sex and gender specificity affects the occurrence,
development, and consequence of a plethora of pathologies. Mitochondria are considered …

[HTML][HTML] Uncovering sex-specific mechanisms of action of testosterone and redox balance

D Cruz-Topete, P Dominic, KY Stokes - Redox Biology, 2020 - Elsevier
The molecular and pharmacological manipulation of the endogenous redox system is a
promising therapy to limit myocardial damage after a heart attack; however, antioxidant …

Sex‐based differences in cardiac ischaemic injury and protection: therapeutic implications

B Ostadal, P Ostadal - British journal of pharmacology, 2014 - Wiley Online Library
Ischaemic heart disease (IHD) is the most frequent cause of mortality among men and
women. Many epidemiological studies have demonstrated that premenopausal women …

Photobiomodulation: evolution and adaptation

NB Lipko - Photobiomodulation, Photomedicine, and Laser …, 2022 - liebertpub.com
Photobiomodulation (PBM) can be described as the intentional use of low-power laser or
light-emitting diode light in the visible and near-infrared light spectra as a medical treatment …

Significant role of estrogen in maintaining cardiac mitochondrial functions

C Rattanasopa, S Phungphong… - The Journal of steroid …, 2015 - Elsevier
Increased susceptibility to stress-induced myocardial damage is a significant concern in
addition to decreased cardiac performance in postmenopausal females. To determine the …

Testosterone deficiency impairs cardiac interfibrillar mitochondrial function and myocardial contractility while inducing oxidative stress

PR do Val Lima, KS Ronconi, EA Morra… - Frontiers in …, 2023 - frontiersin.org
Introduction Clinical studies have shown that low levels of endogenous testosterone are
associated with cardiovascular diseases. Considering the intimate connection between …

Long-term inorganic nitrate administration protects against myocardial ischemia-reperfusion injury in female rats

Y Yassaghi, S Jeddi, N Yousefzadeh, K Kashfi… - BMC Cardiovascular …, 2023 - Springer
Background The favorable effects of nitrate against myocardial ischemia-reperfusion injury
(MIRI) have primarily focused on male rats and in short term. Here we determine the impact …

Apoptosis and autophagy contribute to gender difference in cardiac ischemia–reperfusion induced injury in rats

C Chen, LX Hu, T Dong, GQ Wang, LH Wang, XP Zhou… - Life sciences, 2013 - Elsevier
Aims Gender difference in cardiac ischemia–reperfusion (IR) induced injury has been
reported in animal models. However, a large-scale clinical trial found an increase in …

Sex difference in cardioprotection against acute myocardial infarction in MAO-B knockout mice in vivo

J Heger, T Szabados, P Brosinsky, P Bencsik… - International Journal of …, 2023 - mdpi.com
The cardiomyocyte-specific knockout (KO) of monoamine oxidase (MAO)-B, an enzyme
involved in the formation of reactive oxygen species (ROS), reduced myocardial …