Endocannabinoid system: chemical characteristics and biological activity

B Rezende, AKN Alencar, GF de Bem… - Pharmaceuticals, 2023 - mdpi.com
The endocannabinoid system (eCB) has been studied to identify the molecular structures
present in Cannabis sativa. eCB consists of cannabinoid receptors, endogenous ligands …

Cannabidiol-loaded nanocarriers and their therapeutic applications

E Assadpour, A Rezaei, SS Das, BV Krishna Rao… - Pharmaceuticals, 2023 - mdpi.com
Cannabidiol (CBD), one of the most promising constituents isolated from Cannabis sativa,
exhibits diverse pharmacological actions. However, the applications of CBD are restricted …

Cannabinoids in traumatic brain injury and related neuropathologies: preclinical and clinical research on endogenous, plant-derived, and synthetic compounds

BR Lins, CC Anyaegbu, SC Hellewell, M Papini… - Journal of …, 2023 - Springer
Traumatic brain injury is common, and often results in debilitating consequences. Even mild
traumatic brain injury leaves approximately 20% of patients with symptoms that persist for …

Adverse events of epidiolex: a real-world drug safety surveillance study based on the FDA adverse event reporting system (FAERS) database

Q Zhou, Z Du, K Qu, Y Shen, Y Jiang, H Zhu… - Asian Journal of …, 2023 - Elsevier
Epidiolex, the first FDA-approved drug with cannabis extract, treats Dravet and Lennox-
Gastaut syndromes. Using data from the FAERS database between 2018 and 2023, this …

Combinations of Cannabidiol and Δ9-Tetrahydrocannabinol in Reducing Chemotherapeutic Induced Neuropathic Pain

DE Sepulveda, KE Vrana, NM Graziane… - Biomedicines, 2022 - mdpi.com
Neuropathic pain is a condition that impacts a substantial portion of the population and is
expected to affect a larger percentage in the future. This type of pain is poorly managed by …

Activation of TRPV1 Channels Inhibits the Release of Acetylcholine and Improves Muscle Contractility in Mice

AY Arkhipov, NS Fedorov, LF Nurullin… - Cellular and Molecular …, 2023 - Springer
TRPV1 represents a non-selective transient receptor potential cation channel found not only
in sensory neurons, but also in motor nerve endings and in skeletal muscle fibers. However …

Structural Basis for Molecular Recognition of Cannabinoids by Inhibitory Cys-Loop Channels

LD Alvarez, NR Carina Alves - Journal of Medicinal Chemistry, 2024 - ACS Publications
Cannabis sativa has a long history of medicinal use, dating back to ancient times. This plant
produces cannabinoids, which are now known to interact with several human proteins …

Oxidative stress–mediated proapoptosis signaling: A novel theory on the mechanism underlying the pathogenesis of burning mouth syndrome

S Heiliczer, R Yanko, Y Sharav, DJ Aframian… - The Journal of the …, 2024 - Elsevier
Background Burning mouth syndrome (BMS) is a chronic oral pain disorder characterized by
a generalized burning sensation in the oral mucosa without apparent medical or dental …

CB65 and novel CB65 liposomal system suppress MG63 and Saos-2 osteosarcoma cell growth in vitro

BI Zorba, Ö Boyacıoğlu, T Çağlayan… - Journal of Liposome …, 2024 - Taylor & Francis
Curable approaches for primary osteosarcoma are inadequate and urge investigation of
novel therapeutic formulations. Cannabinoid ligands exert antiproliferative and apoptotic …

[HTML][HTML] Medical Cannabis Prescription Practices and Quality of Life in Thai Patients: A Nationwide Prospective Observational Cohort Study

P Stienrut, K Pongpirul, P Phutrakool… - Medical Cannabis and …, 2024 - karger.com
Introduction: The legalization of cannabis in Thailand has renewed interest in its traditional
medical use. This study aimed to explore the prescribing patterns of traditional practitioners …