The β cell in diabetes: integrating biomarkers with functional measures

SE Kahn, YC Chen, N Esser, AJ Taylor… - Endocrine …, 2021 - academic.oup.com
The pathogenesis of hyperglycemia observed in most forms of diabetes is intimately tied to
the islet β cell. Impairments in propeptide processing and secretory function, along with the …

Genetic risk factors and gene–lifestyle interactions in gestational diabetes

T Jääskeläinen, MM Klemetti - Nutrients, 2022 - mdpi.com
Paralleling the increasing trends of maternal obesity, gestational diabetes (GDM) has
become a global health challenge with significant public health repercussions. In addition to …

Genetic studies of gestational diabetes and glucose metabolism in pregnancy

CE Powe, SH Kwak - Current diabetes reports, 2020 - Springer
Abstract Purpose of Review In this review, we summarize studies investigating genetics of
gestational diabetes mellitus (GDM) and glucose metabolism in pregnancy. We describe …

Genetic risk of type 2 diabetes modifies the effects of a lifestyle intervention aimed at the prevention of gestational and postpartum diabetes

E Huvinen, J Lahti, MM Klemetti, PH Bergman… - Diabetologia, 2022 - Springer
Aims/hypothesis The aim of this study was to assess the interaction between genetic risk
and lifestyle intervention on the occurrence of gestational diabetes mellitus (GDM) and …

Genetic factors and risk of type 2 diabetes among women with a history of gestational diabetes: findings from two independent populations

M Li, ML Rahman, J Wu, M Ding, JE Chavarro… - BMJ Open Diabetes …, 2020 - drc.bmj.com
Objective Women with a history of gestational diabetes mellitus (GDM) have an
exceptionally high risk for type 2 diabetes (T2D). Yet, little is known about genetic …

Genetics and Epigenetics: Implications for the Life Course of Gestational Diabetes

WL Lowe Jr - International journal of molecular sciences, 2023 - mdpi.com
Gestational diabetes (GDM) is one of the most common complications of pregnancy,
affecting as many as one in six pregnancies. It is associated with both short-and long-term …

Prevention of diabetes through lifestyle intervention: lessons learned from the diabetes prevention program and outcomes study and its translation to practice

MA Hoskin, GA Bray, K Hattaway… - Current nutrition …, 2014 - Springer
A number of strategies have been used to delay or prevent the development of type 2
diabetes mellitus (T2D) in high-risk adults, such as diet, exercise, medications, and surgery …

[HTML][HTML] Preexisting diabetes and pregnancy

JL Kitzmiller, A Ferrara, T Peng, MA Cissell, C Kim - 2021 - europepmc.org
The prevalence of diabetes in adolescents and women of reproductive age has increased
since 1995. However, no prospective national population-based data from the United States …

Effects of treatment with metformin and/or sitagliptin on beta‐cell function and insulin resistance in prediabetic women with previous gestational diabetes

G Daniele, A Tura, A Dardano… - Diabetes, Obesity …, 2020 - Wiley Online Library
Aim To investigate the effect of sitagliptin (SITA) and metformin (MET) monotherapy as well
as in combination (MET+ SITA) on beta‐cell function and insulin sensitivity in women with …

Association of single nucleotide polymorphisms with insulin secretion, insulin sensitivity, and diabetes in women with a history of gestational diabetes mellitus

RB Prasad, K Kristensen, A Katsarou, N Shaat - BMC Medical Genomics, 2021 - Springer
Background This study investigated whether single nucleotide polymorphisms (SNPs)
reported by previous genome-wide association studies (GWAS) to be associated with …