Diagnosis of viral gastroenteritis in children: interpretation of real-time PCR results and relation to clinical symptoms

MS Corcoran, GTJ Van Well, IHM Van Loo - European journal of clinical …, 2014 - Springer
Molecular methods such as real-time polymerase chain reaction (PCR) are rapidly replacing
traditional tests to detect fecal viral pathogens in childhood diarrhea. This technique has …

Human and animal viruses in food (including taxonomy of enteric viruses)

GE Greening, JL Cannon - Viruses in foods, 2016 - Springer
In recent years, there has been an increase in the incidence of foodborne diseases
worldwide, with viruses now being recognized as a major cause of these illnesses. The most …

Antigen targeting to M cells for enhancing the efficacy of mucosal vaccines

SH Kim, YS Jang - Experimental & molecular medicine, 2014 - nature.com
Vaccination is one of the most successful applications of immunology and for a long time
has depended on parenteral administration protocols. However, recent studies have pointed …

Whole genome analysis of selected human and animal rotaviruses identified in Uganda from 2012 to 2014 reveals complex genome reassortment events between …

J Bwogi, KC Jere, C Karamagi, DK Byarugaba… - PloS one, 2017 - journals.plos.org
Rotaviruses of species A (RVA) are a common cause of diarrhoea in children and the young
of various other mammals and birds worldwide. To investigate possible interspecies …

In vitro antiviral activity of Lactobacillus casei and Bifidobacterium adolescentis against rotavirus infection monitored by NSP4 protein production

NN Olaya Galán, JC Ulloa Rubiano… - Journal of applied …, 2016 - academic.oup.com
Aims The aim of this study was to determine the antiviral activity of four probiotic metabolites
(Lactobacillus and Bifidobacetrium species) against rotavirus in vitro infection monitored by …

Rotavirus NSP4 triggers secretion of proinflammatory cytokines from macrophages via toll-like receptor 2

Y Ge, A Mansell, JE Ussher, AES Brooks… - Journal of …, 2013 - Am Soc Microbiol
ABSTRACT Nonstructural protein 4 (NSP4), encoded by rotavirus, exhibits various
properties linked to viral pathogenesis, including enterotoxic activity. A recent study (OV …

Overview of the development, impacts, and challenges of live-attenuated oral rotavirus vaccines

OS Folorunso, OM Sebolai - Vaccines, 2020 - mdpi.com
Safety, efficacy, and cost-effectiveness are paramount to vaccine development. Following
the isolation of rotavirus particles in 1969 and its evidence as an aetiology of severe …

How vaccines work: immune effector mechanisms and designer vaccines

S Sell - Expert review of vaccines, 2019 - Taylor & Francis
Introduction: Three major advances have led to increase in length and quality of human life:
increased food production, improved sanitation and induction of specific adaptive immune …

[HTML][HTML] Epithelial WNT ligands are essential drivers of intestinal stem cell activation

WY Zou, SE Blutt, XL Zeng, MS Chen, YH Lo… - Cell reports, 2018 - cell.com
Intestinal stem cells (ISCs) maintain and repair the intestinal epithelium. While regeneration
after ISC-targeted damage is increasingly understood, injury-repair mechanisms that direct …

Whole-genome characterization of common rotavirus strains circulating in Vellore, India from 2002 to 2017: emergence of non-classical genomic constellations

SA Khakha, T Varghese, S Giri, A Durbin, GS Tan… - Gut Pathogens, 2023 - Springer
Rotaviruses (RVs) are the most common etiological agent of acute gastroenteritis among
young children, even after vaccine introduction in low-income countries. A whole-genome …