Immunobiotic Lactobacillus strains reduce small intestinal injury induced by intraepithelial lymphocytes after Toll-like receptor 3 activation
A Tada, H Zelaya, P Clua, S Salva, S Alvarez… - Inflammation …, 2016 - Springer
Abstract Objective Intestinal intraepithelial lymphocytes (IELs) play critical roles in disrupting
epithelial homeostasis after Toll-like receptor (TLR)-3 activation with genomic rotavirus …
epithelial homeostasis after Toll-like receptor (TLR)-3 activation with genomic rotavirus …
[HTML][HTML] TNF-α exerts potent anti-rotavirus effects via the activation of classical NF-κB pathway
MS Hakim, S Ding, S Chen, Y Yin, J Su… - Virus research, 2018 - Elsevier
Active virus-host interactions determine the outcome of pathogen invasions. It has been
shown that in isolated dendritic cells (DCs), rotavirus can induce the expression of tumor …
shown that in isolated dendritic cells (DCs), rotavirus can induce the expression of tumor …
Basal interferon signaling and therapeutic use of interferons in controlling rotavirus infection in human intestinal cells and organoids
Rotavirus (RV) primarily infects enterocytes and results in severe diarrhea, particularly in
children. It is known that the host immune responses determine the outcome of viral …
children. It is known that the host immune responses determine the outcome of viral …
A genome-wide association meta-analysis of diarrhoeal disease in young children identifies FUT2 locus and provides plausible biological pathways
M Bustamante, M Standl, Q Bassat… - Human molecular …, 2016 - academic.oup.com
More than a million childhood diarrhoeal episodes occur worldwide each year, and in
developed countries a considerable part of them are caused by viral infections. In this study …
developed countries a considerable part of them are caused by viral infections. In this study …
Simian rotaviruses possess divergent gene constellations that originated from interspecies transmission and reassortment
J Matthijnssens, ZF Taraporewala, H Yang… - Journal of …, 2010 - Am Soc Microbiol
Although few simian rotaviruses (RVs) have been isolated, such strains have been important
for basic research and vaccine development. To explore the origins of simian RVs, the …
for basic research and vaccine development. To explore the origins of simian RVs, the …
Involvement of main diarrheagenic Escherichia coli, with emphasis on enteroaggregative E. coli, in severe non-epidemic pediatric diarrhea in a high-income country
J Tobias, E Kassem, U Rubinstein, A Bialik… - BMC infectious …, 2015 - Springer
Background Bacterial and viral enteric pathogens are the leading cause of diarrhea in
infants and children. We aimed to identify and characterize the main human diarrheagenic …
infants and children. We aimed to identify and characterize the main human diarrheagenic …
Anti-VP6 VHH: an experimental treatment for rotavirus A-associated disease
L Maffey, CG Vega, S Miño, L Garaicoechea… - PloS one, 2016 - journals.plos.org
Species A Rotaviruses (RVA) remain a leading cause of mortality in children under 5 years
of age. Current treatment options are limited. We assessed the efficacy of two VP6-specific …
of age. Current treatment options are limited. We assessed the efficacy of two VP6-specific …
Immunobiotic lactic acid bacteria beneficially regulate immune response triggered by poly (I: C) in porcine intestinal epithelial cells
S Hosoya, J Villena, T Shimazu, M Tohno, H Fujie… - Veterinary …, 2011 - Springer
This study analyzed the functional expression of TLR3 in various gastrointestinal tissues
from adult swine and shows that TLR3 is expressed preferentially in intestinal epithelial cells …
from adult swine and shows that TLR3 is expressed preferentially in intestinal epithelial cells …
[HTML][HTML] FUT2 secretor genotype and susceptibility to infections and chronic conditions in the ALSPAC cohort
Background: The FUT2 (fucosyltransferase-2) gene determines blood group secretor status.
Being homozygous for the inactive “non-secretor” rs601338 (A) allele confers resistance to …
Being homozygous for the inactive “non-secretor” rs601338 (A) allele confers resistance to …