Can intracellular Staphylococcus aureus in osteomyelitis be treated using current antibiotics? A systematic review and narrative synthesis

AR Zelmer, R Nelson, K Richter, GJ Atkins - Bone research, 2022 - nature.com
Approximately 40% of treatments of chronic and recurrent osteomyelitis fail in part due to
bacterial persistence. Staphylococcus aureus, the predominant pathogen in human …

Staphylococcal trafficking and infection—from 'nose to gut'and back

EJM Raineri, D Altulea… - FEMS microbiology …, 2022 - academic.oup.com
Staphylococcus aureus is an opportunistic human pathogen, which is a leading cause of
infections worldwide. The challenge in treating S. aureus infection is linked to the …

Intracellular Staphylococcus aureus persisters upon antibiotic exposure

F Peyrusson, H Varet, TK Nguyen, R Legendre… - Nature …, 2020 - nature.com
Bacterial persister cells are phenotypic variants that exhibit a transient non-growing state
and antibiotic tolerance. Here, we provide in vitro evidence of Staphylococcus aureus …

Antibacterial biomaterials in bone tissue engineering

ZY Chen, S Gao, YW Zhang, RB Zhou… - Journal of Materials …, 2021 - pubs.rsc.org
Bone infection is a devastating disease characterized by recurrence, drug-resistance, and
high morbidity, that has prompted clinicians and scientists to develop novel approaches to …

Staphylococcus aureus populations from the gut and the blood are not distinguished by virulence traits—a critical role of host barrier integrity

EJM Raineri, S Maaß, M Wang, S Brushett… - Microbiome, 2022 - Springer
Abstract Background The opportunistic pathogen Staphylococcus aureus is an
asymptomatically carried member of the microbiome of about one third of the human …

Intracellular Habitation of Staphylococcus aureus: Molecular Mechanisms and Prospects for Antimicrobial Therapy

JW Hommes, BGJ Surewaard - Biomedicines, 2022 - mdpi.com
Methicillin-resistant Staphylococcus aureus (MRSA) infections pose a global health threat,
especially with the continuous development of antibiotic resistance. As an opportunistic …

In or out: Phagosomal escape of Staphylococcus aureus

A Moldovan, MJ Fraunholz - Cellular microbiology, 2019 - Wiley Online Library
Staphylococcus aureus is internalised by host cells in vivo, and recent research results
suggest that the bacteria use this intracellularity to persist in the host and form a reservoir for …

Intracellular Staphylococcus aureus in bone and joint infections: a mechanism of disease recurrence, inflammation, and bone and cartilage destruction

KD Alder, I Lee, AM Munger, HK Kwon, MT Morris… - Bone, 2020 - Elsevier
Bone and joint infections are devastating afflictions. Although medical interventions and
advents have improved their care, bone and joint infections still portend dismal outcomes …

Streptococcus agalactiae cadD alleviates metal stress and promotes intracellular survival in macrophages and ascending infection during pregnancy

ML Korir, RS Doster, J Lu, MA Guevara… - Nature …, 2022 - nature.com
Perinatal infection with Streptococcus agalactiae, or Group B Streptococcus (GBS), is
associated with preterm birth, neonatal sepsis, and stillbirth. Here, we study the interactions …

Multiple alternative carbon pathways combine to promote Candida albicans stress resistance, immune interactions, and virulence

RB Williams, MC Lorenz - MBio, 2020 - Am Soc Microbiol
The phagocytic cells of the innate immune system are an essential first line of antimicrobial
defense, and yet Candida albicans, one of the most problematic fungal pathogens, is …