[HTML][HTML] COVID-19: ICU delirium management during SARS-CoV-2 pandemic
The novel coronavirus, SARS-CoV-2-causing Coronavirus Disease 19 (COVID-19),
emerged as a public health threat in December 2019 and was declared a pandemic by the …
emerged as a public health threat in December 2019 and was declared a pandemic by the …
[HTML][HTML] Interleukin-1 beta—a friend or foe in malignancies?
R Bent, L Moll, S Grabbe, M Bros - International journal of molecular …, 2018 - mdpi.com
Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune
cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after …
cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after …
[HTML][HTML] α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson's disease
A diagnosis of motor Parkinson's disease (PD) is preceded by a prolonged premotor phase
with accumulating neuronal damage. Here we examined the temporal relation between α …
with accumulating neuronal damage. Here we examined the temporal relation between α …
[HTML][HTML] T-cells produce acidic niches in lymph nodes to suppress their own effector functions
H Wu, V Estrella, M Beatty, D Abrahams… - Nature …, 2020 - nature.com
The acidic pH of tumors profoundly inhibits effector functions of activated CD8+ T-cells. We
hypothesize that this is a physiological process in immune regulation, and that it occurs …
hypothesize that this is a physiological process in immune regulation, and that it occurs …
COVID-19: What do we need to know about ICU delirium during the SARS-CoV-2 pandemic?
Abstract In March 2020, the World Health Organisation announced the COVID-19 pandemic
caused by the SARS-CoV-2 virus. As well as respiratory failure, the SARS-CoV-2 may cause …
caused by the SARS-CoV-2 virus. As well as respiratory failure, the SARS-CoV-2 may cause …
Leaky brain in neurological and psychiatric disorders: Drivers and consequences
G Morris, BS Fernandes, BK Puri… - Australian & New …, 2018 - journals.sagepub.com
Background: The blood–brain barrier acts as a highly regulated interface; its dysfunction
may exacerbate, and perhaps initiate, neurological and neuropsychiatric disorders …
may exacerbate, and perhaps initiate, neurological and neuropsychiatric disorders …
[HTML][HTML] Innate immunity in the central nervous system: a missing piece of the autoimmune encephalitis puzzle?
R Wesselingh, H Butzkueven, K Buzzard… - Frontiers in …, 2019 - frontiersin.org
The autoimmune encephalitides are a group of autoimmune conditions targeting the central
nervous system and causing severe clinical symptoms including drug-resistant seizures …
nervous system and causing severe clinical symptoms including drug-resistant seizures …
Micronuclei, inflammation and auto-immune disease
M Kirsch-Volders, C Bolognesi, M Ceppi… - … Research/Reviews in …, 2020 - Elsevier
Auto-immune diseases (AUD) are characterized by an immune response to antigenic
components of the host itself. The etiology of AUD is not well understood. The available …
components of the host itself. The etiology of AUD is not well understood. The available …
Autoimmune receptor encephalitis in mice induced by active immunization with conformationally stabilized holoreceptors
BE Jones, KR Tovar, A Goehring… - Science translational …, 2019 - science.org
Autoimmunity to membrane proteins in the central nervous system has been increasingly
recognized as a cause of neuropsychiatric disease. A key recent development was the …
recognized as a cause of neuropsychiatric disease. A key recent development was the …
Immunological abnormalities in patients with primary biliary cholangitis
WT Ma, DK Chen - Clinical science, 2019 - portlandpress.com
Primary biliary cholangitis (PBC), an autoimmune liver disease occurring predominantly in
women, is characterized by high titers of serum anti-mitochondrial antibodies (AMAs) and …
women, is characterized by high titers of serum anti-mitochondrial antibodies (AMAs) and …