Safety pharmacology

WS Redfern, ID Wakefield - Toxicological testing handbook …, 2006 - api.taylorfrancis.com
The International Conference on Harmonization of Technical Requirements for Registration
of Pharmaceuticals for Human Use (ICH) has issued a set of international regulatory …

The effects of combined angiotensin converting enzyme inhibition and beta-adrenoceptor blockade on plasma renin activity in anaesthetized dogs.

D Cambridge, MV Whiting, LJ Butterfield… - British journal of …, 1992 - ncbi.nlm.nih.gov
The effects of beta-adrenoceptor blockade on the changes in plasma renin activity (PRA)
following angiotensin enzyme (ACE) inhibition were investigated in pentobarbitone …

Antihypertensive Agents

EW Petriilo Jr, NC Trippodo, JM DeForrest - Annual Reports in Medicinal …, 1990 - Elsevier
Publisher Summary Cardiovascular disease accounts for more expenditures on health care
than any other diagnostic category and hypertension is the most prevalent cardiovascular …

The Pharmacological Background

BJR Whittle, JA Salmon, RM Ferris - Early Phase Drug Evaluation …, 2020 - taylorfrancis.com
This chapter provides the primary consideration to the development of pharmacological
agents as therapeutic drugs, but a similar approach should be adopted for potential …

[引用][C] Preclinical Pharmacology of a Novel Dual Acting Angiotensin Converting Enzyme Inhibitor with β‐Adrenoceptor Blocking Properties

G Allan, D Cambridge, MJ Follenfant… - Cardiovascular Drug …, 1988 - Wiley Online Library
In recent years there has emerged a number of agents that represent a new class of drugs
called hybrid drugs, which combine in one molecule two distinct pharmacological activities …

[引用][C] BACKGROUND AND BASIC PRINCIPLES

WS Redfern - Toxicological Testing Handbook: Principles …, 2006 - Informa Health Care