Peripherally derived macrophages infiltrate the brain after bone marrow transplantation and
during central nervous system (CNS) inflammation. It was initially suggested that these …

All biomaterials, when implanted in vivo, elicit cellular and tissue responses. These
responses include the inflammatory and wound healing responses, foreign body reactions …

Monocytes and macrophages have crucial and distinct roles in tissue homeostasis and
immunity, but they also contribute to a broad spectrum of pathologies and are thus attractive …

Importance Traumatic brain injury (TBI) is a significant public health concern that affects
individuals in all demographics. With increasing interest in the medical and public …

Macrophages are important players in the fight against viral, bacterial, fungal and parasitic
infections. From a resting state they may undertake two activation pathways, the classical …

Long recognized as an evolutionarily ancient cell type involved in tissue homeostasis and
immune defense against pathogens, macrophages are being rediscovered as regulators of …

Macrophages, the most plastic cells of the haematopoietic system, are found in all tissues
and show great functional diversity. They have roles in development, homeostasis, tissue …

Mononuclear phagocytic cells in the CNS used to be defined according to their anatomical
location and surface marker expression. Recently, this concept has been challenged by the …

Macrophages are myeloid immune cells that are strategically positioned throughout the
body tissues, where they ingest and degrade dead cells, debris, and foreign material and …

Multiple sclerosis is a chronic disease of the CNS that leads to substantial disability in most
patients. The early phase is characterised by relapses and the later phase by progressive …