Type 2 chronic inflammatory diseases: targets, therapies and unmet needs

P Kolkhir, CA Akdis, M Akdis, C Bachert… - Nature Reviews Drug …, 2023 - nature.com
Over the past two decades, significant progress in understanding of the pathogenesis of type
2 chronic inflammatory diseases has enabled the identification of compounds for more than …

The IL-4, IL-13 and IL-31 pathways in atopic dermatitis

C Dubin, E Del Duca… - Expert review of clinical …, 2021 - Taylor & Francis
Introduction: Atopic dermatitis (AD) is the most common inflammatory skin disease. It has a
complex pathophysiology, with a combination of immune dysregulation and intrinsic barrier …

[HTML][HTML] Neuroimmune communication regulating pruritus in atopic dermatitis

M Steinhoff, F Ahmad, A Pandey, A Datsi… - Journal of Allergy and …, 2022 - Elsevier
Atopic dermatitis (AD) is a common, chronic-relapsing inflammatory skin disease with
significant disease burden. Genetic and environmental trigger factors contribute to AD …

Pruritus as a distinctive feature of type 2 inflammation

S Garcovich, M Maurelli, P Gisondi, K Peris… - Vaccines, 2021 - mdpi.com
Pruritus is a common symptom of several skin diseases, both inflammatory and neoplastic.
Pruritus might have a tremendous impact on patients' quality of life and strongly interfere …

[HTML][HTML] Attenuating the atopic march: meta-analysis of the dupilumab atopic dermatitis database for incident allergic events

GP Geba, D Li, M Xu, K Mohammadi, R Attre… - Journal of Allergy and …, 2023 - Elsevier
BACKGROUND Atopic march refers to the sequential development of allergic diseases from
infancy through adolescence, typically beginning with atopic dermatitis (AD) followed by …

The hidden sentinel of the skin: An overview on the role of interleukin-13 in atopic dermatitis

M Napolitano, F di Vico, A Ruggiero… - Frontiers in …, 2023 - frontiersin.org
Recent evidence suggests that interleukin (IL)-13 is a crucial cytokine involved in the
pathogenesis of atopic dermatitis (AD). It is a central driver of type-2 T-helper inflammation …

Cellular activation pathways and interaction networks in vascularized composite allotransplantation

L Knoedler, S Knoedler, AC Panayi, CAA Lee… - Frontiers in …, 2023 - frontiersin.org
Vascularized composite allotransplantation (VCA) is an evolving field of reconstructive
surgery that has revolutionized the treatment of patients with devastating injuries, including …

Oral administration of Faecalibacterium prausnitzii and Akkermansia muciniphila strains from humans improves atopic dermatitis symptoms in DNCB induced NC …

Y Lee, HR Byeon, SY Jang, MG Hong, D Kim, D Lee… - Scientific Reports, 2022 - nature.com
Atopic dermatitis (AD) is a common inflammatory skin disease, and its pathogenesis is
closely associated with microbial homeostasis in the gut, namely the gut-skin axis …

The implications of pruritogens in the pathogenesis of atopic dermatitis

LS Wong, YT Yen, CH Lee - International journal of molecular sciences, 2021 - mdpi.com
Atopic dermatitis (AD) is a prototypic inflammatory disease that presents with intense itching.
The pathophysiology of AD is multifactorial, involving environmental factors, genetic …

[HTML][HTML] In vitro disease models for understanding psoriasis and atopic dermatitis

R Sarama, PK Matharu, Y Abduldaiem… - … in Bioengineering and …, 2022 - frontiersin.org
Psoriasis (PS) and Atopic Dermatitis (AD) are two of the most prevalent and misunderstood
inflammatory skin diseases. Dysregulations in the immune response are believed to play a …