With the increasing incidence of cancer worldwide, the need for specific, effective therapies
is ever more urgent. One example of targeted cancer therapeutics is hypoxia-activated …

Purpose: To present and evaluate clinical data suggesting that cancer metastasis may be
induced by the microenvironment of the primary tumour and to discuss possible …

Purpose: Tumor hypoxia adversely affects short term clinical radiation response of head and
neck cancer lymph node metastases and long term disease-free survival (DFS) in cervix …

Hypoxia profoundly influences tumor development and response to therapy. While progress
has been made in identifying individual gene products whose synthesis is altered under …

Background and purpose: Hypoxic tumor cells are known to be relatively radioresistant. The
aim of the study was to correlate oxygenation status and radiation response in advanced …

Hypoxia occurs in two forms in tumors. Chronic or diffusion-limited hypoxia is relatively well
characterized. In contrast, intermittent or perfusion-limited hypoxia is not well characterized …

Background. Tumor hypoxia may be associated with treatment resistance, cell proliferation,
and metastatic potential, which contribute to poor prognosis. Complementary techniques for …

Pimonidazole binding was compared with oxygen electrode measurements and with
measurements of the radiobiologically hypoxic fraction in C3H mammary tumors in which …

Raman spectra of cells and nuclei from cultures in the plateau (nonproliferating) and
exponential (proliferating) phases of growth were measured and show that Raman …

Poor oxygenation (hypoxia) is present in the majority of human tumors and is associated
with poor prognosis due to the protection it affords to radiotherapy and chemotherapy …