How do chemotherapeutic agents damage the ovary?

S Morgan, RA Anderson, C Gourley… - Human reproduction …, 2012 - academic.oup.com
BACKGROUND Chemotherapy treatment in premenopausal women is associated with an
increased risk of premature ovarian failure (POF) but the exact mechanism through which …

Curcumin: a potentially powerful tool to reverse cisplatin-induced toxicity

R Rezaee, AA Momtazi, A Monemi… - Pharmacological research, 2017 - Elsevier
Curcumin is a naturally occurring polyphenol isolated from Curcuma longa that has gained
considerable interest over the last decades due to its beneficial effects for human health …

Comparison of antagonistic effects of nanoparticle-selenium, selenium-enriched yeast and sodium selenite against cadmium-induced cardiotoxicity via AHR/CAR …

J Ge, K Guo, Y Huang, PD Morse, C Zhang… - The Journal of nutritional …, 2022 - Elsevier
Selenium (Se), a nutritionally essential mineral for humans and animals, has a significant
antagonistic effect on heavy metal cadmium (Cd) biotoxicity. Still, the impact of different Se …

Protection of cisplatin-induced spermatotoxicity, DNA damage and chromatin abnormality by selenium nano-particles

MA Rezvanfar, MA Rezvanfar, AR Shahverdi… - Toxicology and applied …, 2013 - Elsevier
Cisplatin (CIS), an anticancer alkylating agent, induces DNA adducts and effectively cross
links the DNA strands and so affects spermatozoa as a male reproductive toxicant. The …

Antioxidant capacity of phenolic compounds separated from tea seed oil in vitro and in vivo

G Liu, W Zhu, J Zhang, D Song, L Zhuang, Q Ma… - Food Chemistry, 2022 - Elsevier
Tea seed oil is rich in phenols with good antioxidant capacity. However, the antioxidant
capacity evaluation of tea seed oil polyphenols is not deep enough, which mainly focusing …

The role of inflammation in cadmium nephrotoxicity: NF-κB comes into view

EHM Hassanein, WR Mohamed, OS Ahmed… - Life Sciences, 2022 - Elsevier
Kidney diseases are major health problem and understanding the underlined mechanisms
that lead to kidney diseases are critical research points with a marked potential impact on …

Endogenous production of ω-3 polyunsaturated fatty acids mitigates cisplatin-induced myelosuppression by regulating NRF2-MDM2-p53 signaling pathway

Q Xu, Z Zhang, M Tang, C Xing, H Chen… - Free Radical Biology …, 2023 - Elsevier
Cisplatin is a chemotherapy medication used to treat a wide range of cancers. A common
side effect of cisplatin is myelosuppression. Research suggests that oxidative damages are …

Role of ferroptosis in cisplatin-induced acute nephrotoxicity in mice

Y Ikeda, H Hamano, Y Horinouchi, L Miyamoto… - Journal of Trace …, 2021 - Elsevier
Background Cisplatin is widely used as an antitumor drug for the treatment of solid tumors.
However, its use has been limited owing to nephrotoxicity, a major side effect. The …

Protective effects of boron on cyclophosphamide induced lipid peroxidation and genotoxicity in rats

S Ince, I Kucukkurt, HH Demirel, DA Acaroz, E Akbel… - Chemosphere, 2014 - Elsevier
The aim of the present study was to evaluate the possible protective effect of boron (B) on
cyclophosphamide (CYC) induced oxidative stress in rats. Totally, thirty Wistar albino male …

Microfluidic platform for synthesis and optimization of chitosan-coated magnetic nanoparticles in cisplatin delivery

S Siavashy, M Soltani, F Ghorbani-Bidkorbeh… - Carbohydrate …, 2021 - Elsevier
In this study, magnetic core/chitosan shell Nanoparticles (NPs) containing cisplatin were
synthesized via cisplatin complexation with tripolyphosphate as the chitosan crosslinker …