[HTML][HTML] New opportunities and challenges of natural products research: When target identification meets single-cell multiomics

Y Zhu, Z Ouyang, H Du, M Wang, J Wang, H Sun… - … Pharmaceutica Sinica B, 2022 - Elsevier
Natural products, and especially the active ingredients found in traditional Chinese medicine
(TCM), have a thousand-year-long history of clinical use and a strong theoretical basis in …

Cardio-oncology: mechanisms, drug combinations, and reverse cardio-oncology

Z Liang, Y He, X Hu - International Journal of Molecular Sciences, 2022 - mdpi.com
Chemotherapy, radiotherapy, targeted therapy, and immunotherapy have brought hope to
cancer patients. With the prolongation of survival of cancer patients and increased clinical …

Berberine Suppresses Stemness and Tumorigenicity of Colorectal Cancer Stem-Like Cells by Inhibiting m6A Methylation

Z Zhao, J Zeng, Q Guo, K Pu, Y Yang, N Chen… - Frontiers in …, 2021 - frontiersin.org
Background Cancer stem cells (CSCs) are able to survive after cancer therapies, resulting in
tumor progression and recurrence, as is seen in colorectal cancer. Therapies targeting …

The adiponectin signalling pathway-A therapeutic target for the cardiac complications of type 2 diabetes?

A Sharma, M Mah, RH Ritchie, MJ De Blasio - Pharmacology & …, 2022 - Elsevier
Diabetes is associated with an increased risk of heart failure (HF). This is commonly termed
diabetic cardiomyopathy and is often characterised by increased cardiac fibrosis …

Natural compounds as lactate dehydrogenase inhibitors: Potential therapeutics for lactate dehydrogenase inhibitors-related diseases

JH Han, EJ Lee, W Park, KT Ha… - Frontiers in …, 2023 - frontiersin.org
Lactate dehydrogenase (LDH) is a crucial enzyme involved in energy metabolism and
present in various cells throughout the body. Its diverse physiological functions encompass …

[HTML][HTML] Modulation of the nitric oxide/cGMP pathway in cardiac contraction and relaxation: Potential role in heart failure treatment

R Mollace, F Scarano, I Bava, C Carresi… - Pharmacological …, 2023 - Elsevier
Evidence exists that heart failure (HF) has an overall impact of 1-2% in the global population
being often associated with comorbidities that contribute to increased disease prevalence …

[HTML][HTML] The effects of berberine supplementation on cardiovascular risk factors in adults: A systematic review and dose-response meta-analysis

M Zamani, M Zarei, M Nikbaf-Shandiz, S Hosseini… - Frontiers in …, 2022 - frontiersin.org
Cardiovascular disease (CVD) is a major concern today. Herbal medicine is one helping
way to control CVD risks. One conclusive of herbal medicine is Berberine (BBR) and …

Diagnostic and therapeutic aptamers: a promising pathway to improved cardiovascular disease management

V Di Mauro, FC Lauta, J Modica, SL Appleton… - Basic to Translational …, 2024 - jacc.org
Despite advances in care, cardiovascular diseases remain the leading cause of death
worldwide. As a result, identifying suitable biomarkers for early diagnosis and improving …

Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission and Ca2+ homeostasis in a murine model of HFpEF

M Abudureyimu, M Yang, X Wang, X Luo, J Ge… - Frontiers of …, 2023 - Springer
Heart failure with preserved ejection fraction (HFpEF) displays normal or near-normal left
ventricular ejection fraction, diastolic dysfunction, cardiac hypertrophy, and poor exercise …

Berberine hydrochloride alleviates imatinib mesylate–induced cardiotoxicity through the inhibition of Nrf2-dependent ferroptosis

C Song, D Li, J Zhang, X Zhao - Food & Function, 2023 - pubs.rsc.org
Imatinib mesylate (IMA) belonging to the selective tyrosine kinase inhibitor family has been
proven to induce cardiotoxic effects along with therapeutic strategies. Nrf2-dependent …