Epithelial-to-mesenchymal transition (EMT) mechanism is responsible for metastasis and
migration of cancer cells to neighboring cells and tissues. Morphologically, epithelial cells …

Breast cancer, specifically metastatic breast, is a leading cause of morbidity and mortality in
women. This is mainly due to relapse and reoccurrence of tumor. The primary reason for …

Breast cancer exhibits various epigenetic abnormalities that regulate gene expression and
contribute to tumor characteristics. Epigenetic alterations play a significant role in cancer …

In recent years, gene therapy based on miRNA has been employed as a potential growing
technique for treating various co-morbidities. Direct administration of miRNA is unrealistic …

Chitosan is a naturally occurring polymer derived from the deacetylation of chitin, which is
an abundant carbohydrate found mainly in the shells of various marine and terrestrial …

Aim Exosomes, as a nanocarrier for the co-delivery of biologicals and small anticancer
molecules is yet in its infancy. Herein, we investigated hUCBMSC derived exosomes as a …

The tumor-microenvironment (TME) is an amalgamation of various factors derived from
malignant cells and infiltrating host cells, including cells of the immune system. One of the …

Vectorization of microRNAs has shown to be a smart approach for their potential delivery to
treat many diseases (ie, cancer, osteopathy, vascular, and infectious diseases). However …

Glioblastoma multiforme (GBM) is a lethal malignant tumor accounting for 42% of the tumors
of the central nervous system, the median survival being 15 months. At present, no curative …

Current delivery of chemotherapy, either intra-venous or intra-arterial, remains suboptimal
for patients with head and neck tumors. The free form of chemotherapy drugs, such as …