Luteinizing hormone action in human oocyte maturation and quality: signaling pathways, regulation, and clinical impact

A Arroyo, B Kim, J Yeh - Reproductive Sciences, 2020 - Springer
The ovarian follicle luteinizing hormone (LH) signaling molecules that regulate oocyte
meiotic maturation have recently been identified. The LH signal reduces preovulatory follicle …

The stemness of human ovarian granulosa cells and the role of resveratrol in the differentiation of MSCs—a review based on cellular and molecular knowledge

M Jozkowiak, G Hutchings, M Jankowski, K Kulcenty… - Cells, 2020 - mdpi.com
Ovarian Granulosa Cells (GCs) are known to proliferate in the developing follicle and
undergo several biochemical processes during folliculogenesis. They represent a …

Intrafollicular concentrations of the oocyte-secreted factors GDF9 and BMP15 vary inversely in polycystic ovaries

SG Kristensen, A Kumar, LS Mamsen… - The Journal of …, 2022 - academic.oup.com
Context The oocyte-secreted factors growth differentiation factor 9 (GDF9) and bone
morphogenetic protein 15 (BMP15) play essential roles in follicle development and oocyte …

[HTML][HTML] The molecular regulation in the pathophysiology in ovarian aging

CJ Li, LT Lin, HW Tsai, CU Chern, ZH Wen… - Aging and …, 2021 - ncbi.nlm.nih.gov
The female reproductive system is of great significance to women's health. Aging of the
female reproductive system occurs approximately 10 years prior to the natural age …

Estrogen disorders: Interpreting the abnormal regulation of aromatase in granulosa cells

T Liu, Y Huang, H Lin - International Journal of …, 2021 - spandidos-publications.com
Ovarian granulosa cells (GCs) are the most important source of estrogen. Therefore,
aromatase (estrogen synthase), which is the key enzyme in estrogen synthesis, is not only …

[HTML][HTML] Rescue of bmp15 deficiency in zebrafish by mutation of inha reveals mechanisms of BMP15 regulation of folliculogenesis

Y Zhai, X Zhang, C Zhao, R Geng, K Wu, M Yuan… - Plos …, 2023 - journals.plos.org
As an oocyte-specific growth factor, bone morphogenetic protein 15 (BMP15) plays a critical
role in controlling folliculogenesis. However, the mechanism of BMP15 action remains …

[HTML][HTML] Intercellular communication in the cumulus–oocyte complex during folliculogenesis: A review

J Xie, X Xu, S Liu - Frontiers in Cell and Developmental Biology, 2023 - frontiersin.org
During folliculogenesis, the oocyte and surrounding cumulus cells form an ensemble called
the cumulus-oocyte complex (COC). Due to their interdependence, research on the COC …

Age-related decline in the expression of GDF9 and BMP15 genes in follicle fluid and granulosa cells derived from poor ovarian responders

Y Gong, J Li-Ling, D Xiong, J Wei, T Zhong… - Journal of Ovarian …, 2021 - Springer
Background Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15
(BMP15) genes play important roles in folliculogenesis. Altered expression of the two have …

Regulation of aromatase in cancer

D Molehin, F Rasha, RL Rahman, K Pruitt - Molecular and Cellular …, 2021 - Springer
The regulation of aromatase, an enzyme involved in the biosynthesis of estrogen in normal
and cancer cells, has been associated with growth factor signaling and immune response …

Randomised controlled trial on the effect of clomiphene citrate and gonadotropin dose on ovarian response markers and IVF outcomes in poor responders

R Moffat, C Hansali, A Schoetzau, A Ahler… - Human …, 2021 - academic.oup.com
STUDY QUESTION Does the gonadotropin (GN) starting dose and the addition of
clomiphene citrate (CC) during the early follicular phase influence oocyte yield in poor …