Lipid nanoparticles─ from liposomes to mRNA vaccine delivery, a landscape of research diversity and advancement
R Tenchov, R Bird, AE Curtze, Q Zhou - ACS nano, 2021 - ACS Publications
Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising
vehicles to deliver a variety of therapeutics. Currently in the spotlight as vital components of …
vehicles to deliver a variety of therapeutics. Currently in the spotlight as vital components of …
Chemistries of bifunctional PROTAC degraders
C Cao, M He, L Wang, Y He, Y Rao - Chemical Society Reviews, 2022 - pubs.rsc.org
Proteolysis targeting chimeras (PROTACs) technology is a novel and promising therapeutic
strategy using small molecules to induce ubiquitin-dependent degradation of proteins. It has …
strategy using small molecules to induce ubiquitin-dependent degradation of proteins. It has …
PROTACs: great opportunities for academia and industry (an update from 2020 to 2021)
M He, C Cao, Z Ni, Y Liu, P Song, S Hao, Y He… - … and Targeted Therapy, 2022 - nature.com
Abstract PROteolysis TArgeting Chimeras (PROTACs) technology is a new protein-
degradation strategy that has emerged in recent years. It uses bifunctional small molecules …
degradation strategy that has emerged in recent years. It uses bifunctional small molecules …
Nanoparticle uptake: the phagocyte problem
HH Gustafson, D Holt-Casper, DW Grainger… - Nano today, 2015 - Elsevier
Phagocytes are key cellular participants determining important aspects of host exposure to
nanomaterials, initiating clearance, biodistribution and the tenuous balance between host …
nanomaterials, initiating clearance, biodistribution and the tenuous balance between host …
[HTML][HTML] Sol–gel based materials for biomedical applications
Sol–gel chemistry offers a flexible approach to obtaining a diverse range of materials. It
allows differing chemistries to be achieved as well as offering the ability to produce a wide …
allows differing chemistries to be achieved as well as offering the ability to produce a wide …
pH-sensitive delivery vehicle based on folic acid-conjugated polydopamine-modified mesoporous silica nanoparticles for targeted cancer therapy
W Cheng, J Nie, L Xu, C Liang, Y Peng… - … applied materials & …, 2017 - ACS Publications
In this study, we introduced a targeting polymer poly (ethylene glycol)–folic acid (PEG–FA)
on the surface of polydopamine (PDA)-modified mesoporous silica nanoparticles (MSNs) to …
on the surface of polydopamine (PDA)-modified mesoporous silica nanoparticles (MSNs) to …
Light-activatable red blood cell membrane-camouflaged dimeric prodrug nanoparticles for synergistic photodynamic/chemotherapy
Biomimetic approach offers numerous opportunities to design therapeutic platforms with
enhanced antitumor performance and biocompatibility. Herein we report red blood cell …
enhanced antitumor performance and biocompatibility. Herein we report red blood cell …
Hyaluronic acid targeting of CD44 for cancer therapy: from receptor biology to nanomedicine
G Mattheolabakis, L Milane, A Singh… - Journal of drug …, 2015 - Taylor & Francis
Abstract Cluster of differentiation-44 (CD44) is a ubiquitously present glycoprotein on the
surface of mammalian cells that plays a significant role in a number of biological functions …
surface of mammalian cells that plays a significant role in a number of biological functions …
Nanocarriers for cancer-targeted drug delivery
Nanoparticles as drug delivery system have received much attention in recent years,
especially for cancer treatment. In addition to improving the pharmacokinetics of the loaded …
especially for cancer treatment. In addition to improving the pharmacokinetics of the loaded …
Targeted polymeric therapeutic nanoparticles: design, development and clinical translation
N Kamaly, Z Xiao, PM Valencia… - Chemical Society …, 2012 - pubs.rsc.org
Polymeric materials have been used in a range of pharmaceutical and biotechnology
products for more than 40 years. These materials have evolved from their earlier use as …
products for more than 40 years. These materials have evolved from their earlier use as …