Tumor-associated inflammation is predictive of poor prognosis and drives a variety of
tumorigenic phenotypes, including tumor proliferation and survival, angiogenesis …

The cause of Crohn's disease (CD) remains poorly understood. Counterintuitively, these
patients possess an impaired acute inflammatory response, which could result in delayed …

Intrinsic innate immune mechanisms are the first line of defense against pathogens and exist
to control infection autonomously in infected cells. Here, we showed that autophagy, an …

Autophagy was viewed until very recently primarily as a metabolic and intracellular biomass
and organelle quality and quantity control pathway. It has now been recognized that …

The variable efficacy of Bacille Calmette Guerin (BCG) vaccination against tuberculosis has
prompted efforts to improve the vaccine. In this study, we used autophagy to enhance …

Viral proteins are usually processed by the'classical'major histocompatibility complex (MHC)
class I presentation pathway. Here we showed that although macrophages infected with …

Autophagy, a process of self-digestion of the cytoplasm and organelles through which
cellular components are recycled for reuse or energy production, is an evolutionarily …

Autophagy is a process traditionally known to contribute to cellular cleaning through the
removal of intracellular components in lysosomes. In recent years, intensive scrutiny at the …

ALS is a fatal motor neuron disease of adult onset. Neuroinflammation contributes to ALS
disease progression; however, the inflammatory trigger remains unclear. We report that ALS …

Infections elicit diverse responses in the host that include activation of the innate immune
system, inflammation and cell death. Pathogen-triggered cell death is manifested by various …