Innate immune system provides the first line of defense against pathogenic organisms. It has
a varied and large collection of molecules known as pattern recognition receptors (PRRs) …

Macroautophagy/autophagy is a conserved ubiquitous pathway that performs diverse roles
in health and disease. Although many key, widely expressed proteins that regulate …

Intracellular pathogens like Shigella flexneri enter host cells by phagocytosis. Once inside,
the pathogen breaks the vacuolar membrane for cytosolic access. The fate and function of …

Cancer cells have an increased demand for energy sources to support accelerated rates of
growth. When nutrients become limiting, cancer cells may switch to nonconventional energy …

An immunomodulatory role for vitamin D was first proposed more than 25 years ago, based
on two salient observations. Firstly it was shown that monocytes/macrophages from patients …

Autophagy, an evolutionally conserved homeostatic process for catabolizing cytoplasmic
components, has been linked to the elimination of intracellular pathogens during …

Actin-based motility is used by various pathogens for dissemination within and between
cells. Yet host factors restricting this process have not been identified. Septins are GTP …

In human monocytes, Toll‐like receptor (TLR) 2/1 activation leads to vitamin D3‐dependent
antimycobacterial activities, but the molecular mechanisms by which TLR2/1 stimulation …

Autophagy has been recently demonstrated to control cell and tissue homeostasis, including
the functions of various metabolic tissues. However, it remains unclear whether autophagy is …

Cell death mechanisms have been associated with the development of inflammatory bowel
diseases in humans and mice. Recent studies suggested that a complex crosstalk between …