TLRs/NLRs: Shaping the landscape of host immunity
Innate immune system provides the first line of defense against pathogenic organisms. It has
a varied and large collection of molecules known as pattern recognition receptors (PRRs) …
a varied and large collection of molecules known as pattern recognition receptors (PRRs) …
The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion
Macroautophagy/autophagy is a conserved ubiquitous pathway that performs diverse roles
in health and disease. Although many key, widely expressed proteins that regulate …
in health and disease. Although many key, widely expressed proteins that regulate …
Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy
N Dupont, S Lacas-Gervais, J Bertout, I Paz, B Freche… - Cell host & …, 2009 - cell.com
Intracellular pathogens like Shigella flexneri enter host cells by phagocytosis. Once inside,
the pathogen breaks the vacuolar membrane for cytosolic access. The fate and function of …
the pathogen breaks the vacuolar membrane for cytosolic access. The fate and function of …
MiT/TFE family of transcription factors, lysosomes, and cancer
RM Perera, C Di Malta, A Ballabio - Annual review of cancer …, 2019 - annualreviews.org
Cancer cells have an increased demand for energy sources to support accelerated rates of
growth. When nutrients become limiting, cancer cells may switch to nonconventional energy …
growth. When nutrients become limiting, cancer cells may switch to nonconventional energy …
Vitamin D and the intracrinology of innate immunity
M Hewison - Molecular and cellular endocrinology, 2010 - Elsevier
An immunomodulatory role for vitamin D was first proposed more than 25 years ago, based
on two salient observations. Firstly it was shown that monocytes/macrophages from patients …
on two salient observations. Firstly it was shown that monocytes/macrophages from patients …
Autophagic control of listeria through intracellular innate immune recognition in drosophila
T Yano, S Mita, H Ohmori, Y Oshima, Y Fujimoto… - Nature …, 2008 - nature.com
Autophagy, an evolutionally conserved homeostatic process for catabolizing cytoplasmic
components, has been linked to the elimination of intracellular pathogens during …
components, has been linked to the elimination of intracellular pathogens during …
[HTML][HTML] Entrapment of intracytosolic bacteria by septin cage-like structures
Actin-based motility is used by various pathogens for dissemination within and between
cells. Yet host factors restricting this process have not been identified. Septins are GTP …
cells. Yet host factors restricting this process have not been identified. Septins are GTP …
Mycobacterial lipoprotein activates autophagy via TLR2/1/CD14 and a functional vitamin D receptor signalling
DM Shin, JM Yuk, HM Lee, SH Lee, JW Son… - Cellular …, 2010 - Wiley Online Library
In human monocytes, Toll‐like receptor (TLR) 2/1 activation leads to vitamin D3‐dependent
antimycobacterial activities, but the molecular mechanisms by which TLR2/1 stimulation …
antimycobacterial activities, but the molecular mechanisms by which TLR2/1 stimulation …
Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IκB kinase β (IKKβ)/NF-κB pathway
Q Meng, D Cai - Journal of Biological Chemistry, 2011 - ASBMB
Autophagy has been recently demonstrated to control cell and tissue homeostasis, including
the functions of various metabolic tissues. However, it remains unclear whether autophagy is …
the functions of various metabolic tissues. However, it remains unclear whether autophagy is …
Cell death and inflammatory bowel diseases: apoptosis, necrosis, and autophagy in the intestinal epithelium
T Nunes, C Bernardazzi… - BioMed research …, 2014 - Wiley Online Library
Cell death mechanisms have been associated with the development of inflammatory bowel
diseases in humans and mice. Recent studies suggested that a complex crosstalk between …
diseases in humans and mice. Recent studies suggested that a complex crosstalk between …