Cysteine and resistance to oxidative stress: implications for virulence and antibiotic resistance
A Tikhomirova, MM Rahman, SP Kidd, RL Fererro… - Trends in …, 2024 - cell.com
Reactive oxygen species (ROS), including the superoxide radical anion (O 2•–), hydrogen
peroxide (H 2 O 2), and the hydroxyl radical (• HO), are inherent components of bacterial …
peroxide (H 2 O 2), and the hydroxyl radical (• HO), are inherent components of bacterial …
Detection of Streptococcus pyogenes M1UK in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA
A new variant of Streptococcus pyogenes serotype M1 (designated 'M1UK') has been
reported in the United Kingdom, linked with seasonal scarlet fever surges, marked increase …
reported in the United Kingdom, linked with seasonal scarlet fever surges, marked increase …
Interplay between group A Streptococcus and host innate immune responses
MSW Su, YL Cheng, YS Lin, JJ Wu - Microbiology and Molecular …, 2024 - Am Soc Microbiol
SUMMARY Group A Streptococcus (GAS), also known as Streptococcus pyogenes, is a
clinically well-adapted human pathogen that harbors rich virulence determinants …
clinically well-adapted human pathogen that harbors rich virulence determinants …
A newly identified flavoprotein disulfide reductase Har protects Streptococcus pneumoniae against hypothiocyanous acid
Hypothiocyanous acid (HOSCN) is an antimicrobial oxidant produced from hydrogen
peroxide and thiocyanate anions by heme peroxidases in secretory fluids such as in the …
peroxide and thiocyanate anions by heme peroxidases in secretory fluids such as in the …
Emerging roles of low-molecular-weight thiols at the host–microbe interface
DG Dumitrescu, SK Hatzios - Current Opinion in Chemical Biology, 2023 - Elsevier
Abstract Low-molecular-weight (LMW) thiols are an abundant class of cysteine-derived
small molecules found in all forms of life that maintain reducing conditions within cells. While …
small molecules found in all forms of life that maintain reducing conditions within cells. While …
[HTML][HTML] Resisting death by metal: metabolism and Cu/Zn homeostasis in bacteria
MJ Sullivan, I Terán, KGK Goh… - Emerging Topics in Life …, 2024 - portlandpress.com
Metal ions such as zinc and copper play important roles in host–microbe interactions and
their availability can drastically affect the survival of pathogenic bacteria in a host niche …
their availability can drastically affect the survival of pathogenic bacteria in a host niche …
The neutrophil oxidant hypothiocyanous acid causes a thiol-specific stress response and an oxidative shift of the bacillithiol redox potential in Staphylococcus aureus
VV Loi, T Busche, F Schnaufer, J Kalinowski… - Microbiology …, 2023 - Am Soc Microbiol
During infections, Staphylococcus aureus is exposed to hypochlorous acid (HOCl) and
hypothiocyanous acid (HOSCN), which are produced by the neutrophil myeloperoxidase as …
hypothiocyanous acid (HOSCN), which are produced by the neutrophil myeloperoxidase as …
Listeria monocytogenes GshF contributes to oxidative stress tolerance via regulation of the phosphoenolpyruvate-carbohydrate phosphotransferase system
M Chen, J Zhang, J Xia, J Sun, X Zhang… - Microbiology …, 2023 - Am Soc Microbiol
Glutathione (GSH) is an essential component of the glutaredoxin (Grx) system, and it is
synthesized by the enzyme glutathione synthase GshF in Listeria monocytogenes. GSH …
synthesized by the enzyme glutathione synthase GshF in Listeria monocytogenes. GSH …
The glutathione import system satisfies the Staphylococcus aureus nutrient sulfur requirement and promotes interspecies competition
Sulfur is an indispensable element for bacterial proliferation. Prior studies demonstrated that
the human pathogen Staphylococcus aureus utilizes glutathione (GSH) as a source of …
the human pathogen Staphylococcus aureus utilizes glutathione (GSH) as a source of …
Host-mediated copper stress is not protective against Streptococcus pneumoniae D39 infection
Metal ions are required by all organisms for the chemical processes that support life.
However, in excess they can also exert toxicity within biological systems. During infection …
However, in excess they can also exert toxicity within biological systems. During infection …