An ideal animal model of atherosclerosis resembles human anatomy and pathophysiology
and has the potential to be used in medical and pharmaceutical research to obtain results …

Plaque rupture, usually of a precursor lesion known as a'vulnerable plaque'or'thin-cap
fibroatheroma', is the leading cause of thrombosis. Less-frequent aetiologies of coronary …

Background Increasing evidence suggests that atherosclerotic plaque composition rather
than plaque size is linked to ischemic cardiovascular events, yet largescale population …

Although mortality rates from coronary heart disease in the western countries have declined
in the last few decades, morbidity caused by this disease is increasing and a substantial …

Atherosclerosis causes clinical disease through luminal narrowing or by precipitating
thrombi that obstruct blood flow to the heart (coronary heart disease), brain (ischemic …

Intake of hemoglobin by the hemoglobin-haptoglobin receptor CD163 leads to a distinct
alternative non–foam cell antiinflammatory macrophage phenotype that was previously …

The vascular endothelial growth factor (VEGF), a homodimeric vasoactive glycoprotein, is
the key mediator of angiogenesis. Angiogenesis, the formation of new blood vessels, is …

Atherosclerotic plaque rupture with luminal thrombosis is the most common mechanism
responsible for the majority of acute coronary syndromes and sudden coronary death. The …

Plaque microvascularization and increased endothelial permeability are key players in the
development of atherosclerosis, from the initial stages of plaque formation to the occurrence …

Heme is an essential molecule expressed ubiquitously all through our tissues. Heme plays
major functions in cellular physiology and metabolism as the prosthetic group of diverse …