[HTML][HTML] Catalytic activities of a highly efficient cocaine hydrolase for hydrolysis of biologically active cocaine metabolites norcocaine and benzoylecgonine
Cocaine is a widely abused, hepatotoxic drug without an FDA-approved pharmacotherapy
specific for cocaine addiction or overdose. It is recognized as a promising therapeutic …
specific for cocaine addiction or overdose. It is recognized as a promising therapeutic …
Human Butyrylcholinesterase Mutants for (−)-Cocaine Hydrolysis: A Correlation Relationship between Catalytic Efficiency and Total Hydrogen Bonding Energy with an …
F Zheng, S Hou, L Xue, W Yang… - The Journal of Physical …, 2023 - ACS Publications
A combined computational and experimental study has been carried out to explore and test
a quantitative correlation relationship between the relative catalytic efficiency (RCE) of …
a quantitative correlation relationship between the relative catalytic efficiency (RCE) of …
[HTML][HTML] In vitro and in vivo stability of a highly efficient long-acting cocaine hydrolase
It is recognized as a promising therapeutic strategy for cocaine use disorder to develop an
efficient enzyme which can rapidly convert cocaine to physiologically inactive metabolites …
efficient enzyme which can rapidly convert cocaine to physiologically inactive metabolites …
[HTML][HTML] Long-lasting blocking of interoceptive effects of cocaine by a highly efficient cocaine hydrolase in rats
Cocaine dependence is a serious world-wide public health problem without an FDA-
approved pharmacotherapy. We recently designed and discovered a highly efficient long …
approved pharmacotherapy. We recently designed and discovered a highly efficient long …
Kinetic characterization of an efficient cocaine hydrolase against toxic metabolites of cocaine
In the presence of alcohol, cocaine metabolism produces a number of metabolites, including
three toxic ones (cocaethylene, norcocaine, and norcocaethylene) which are all more toxic …
three toxic ones (cocaethylene, norcocaine, and norcocaethylene) which are all more toxic …
The influence of acute dopamine transporter inhibition on manic-, depressive-like phenotypes, and brain oxidative status in adult zebrafish
J Canzian, JV Borba, J Ames, RM Silva… - Progress in Neuro …, 2024 - Elsevier
Functional changes in dopamine transporter (DAT) are related to various psychiatric
conditions, including bipolar disorder (BD) symptoms. In experimental research, the …
conditions, including bipolar disorder (BD) symptoms. In experimental research, the …
[HTML][HTML] Are there prevalent sex differences in psychostimulant use disorder? A focus on the potential therapeutic efficacy of atypical dopamine uptake inhibitors
M Hersey, MK Bartole, CS Jones, AH Newman… - Molecules, 2023 - mdpi.com
Psychostimulant use disorders (PSUD) affect a growing number of men and women and
exert sizable public health and economic burdens on our global society. Notably, there are …
exert sizable public health and economic burdens on our global society. Notably, there are …