Atherosclerosis remains a major cause of morbidity and mortality worldwide, and a thorough
understanding of the underlying pathophysiological mechanisms is crucial for the …

Acute cardiovascular events, due to rupture or erosion of an atherosclerotic plaque,
represent the major cause of morbidity and mortality in patients. Growing evidence suggests …

Clinical evidence links arterial calcification and cardiovascular risk. Finite-element modelling
of the stress distribution within atherosclerotic plaques has suggested that subcellular …

In this article, we advance a hypothesis for the rupture of thin fibrous cap atheroma, namely
that minute (10-μm-diameter) cellular-level microcalcifications in the cap, which heretofore …

Atherosclerosis is a common arterial disease which alters the stiffness of arterial wall.
Arterial stiffness is related to many cardiovascular diseases. In this investigation, maximum …

Events responsible for cardiovascular mortality and morbidity are predominantly caused by
rupture of “vulnerable” atherosclerotic lesions. Vascular smooth muscle cells (VSMCs) play …

Objectives: The purpose of the present study was to assess the relationship between shear
stress distribution and coronary plaque rupture by means of a new color-mapping program …

Fibrous cap thickness is often considered as diagnostic of the degree of plaque instability.
Necrotic core area (Corearea) and the arterial remodeling index (Remodindex), on the other …

Extracellular vesicles (EVs) are nanosized membrane-bound structures released by cells
that are able to transfer nucleic acids, protein cargos, and metabolites to specific recipient …

Atherothrombotic vascular diseases, such as myocardial infarction and stroke, are the
leading causes of death in the industrialized world. The immediate cause of these diseases …